PMID- 22683063
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20211021
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Print)
IS  - 0161-6420 (Linking)
VI  - 119
IP  - 8
DP  - 2012 Aug
TI  - Visualization of the conventional outflow pathway in the living human eye.
PG  - 1563-8
LID - 10.1016/j.ophtha.2012.02.032 [doi]
AB  - PURPOSE: We sought to visualize the aqueous outflow system in 3 dimensions (3D) 
      in living human eyes, and to investigate the use of commercially available 
      spectral-domain optical coherence tomographic (SD-OCT) systems for this purpose. 
      DESIGN: Prospective, observational study. PARTICIPANTS: One randomly determined 
      eye in each of 6 normal healthy subjects was included. TESTING: We performed 3D 
      SD-OCT imaging of the aqueous humor outflow structures with 2 devices: The Cirrus 
      HD-OCT and the Bioptigen SDOIS. MAIN OUTCOME MEASURES: We created 3D virtual 
      castings of Schlemm's canal (SC) and more distal outflow structures from scan 
      data from each device. RESULTS: Virtual casting of the SC provided visualization 
      of more aqueous vessels branching from SC than could be located by interrogating 
      the 2-dimensional (2D) image stack. Similarly, virtual casting of distal 
      structures allowed visualization of large and small aqueous outflow channel 
      networks that could not be appreciated with conventional 2D visualization. 
      CONCLUSIONS: The outflow pathways from SC to the superficial vasculature can be 
      identified and tracked in living human eyes using commercially available SD-OCT.
CI  - Copyright (c) 2012 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Kagemann, Larry
AU  - Kagemann L
AD  - Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, 
      Ophthalmology and Visual Science Research Center, University of Pittsburgh School 
      of Medicine, Pittsburgh, Pennsylvania, USA.
FAU - Wollstein, Gadi
AU  - Wollstein G
FAU - Ishikawa, Hiroshi
AU  - Ishikawa H
FAU - Nadler, Zachary
AU  - Nadler Z
FAU - Sigal, Ian A
AU  - Sigal IA
FAU - Folio, Lindsey S
AU  - Folio LS
FAU - Schuman, Joel S
AU  - Schuman JS
LA  - eng
GR  - R01-EY13178/EY/NEI NIH HHS/United States
GR  - R01 EY013178-12/EY/NEI NIH HHS/United States
GR  - P30 EY008098/EY/NEI NIH HHS/United States
GR  - R01 EY013178/EY/NEI NIH HHS/United States
GR  - P30-EY08098/EY/NEI NIH HHS/United States
GR  - R01 EY013178-11/EY/NEI NIH HHS/United States
GR  - P30 EY008098-21/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120608
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Adult
MH  - *Anatomy, Cross-Sectional
MH  - Aqueous Humor/*metabolism
MH  - Female
MH  - Humans
MH  - *Imaging, Three-Dimensional
MH  - Intraocular Pressure/physiology
MH  - Limbus Corneae/*anatomy & histology/metabolism
MH  - Male
MH  - Prospective Studies
MH  - *Tomography, Optical Coherence
MH  - Trabecular Meshwork/*anatomy & histology/metabolism
PMC - PMC3411861
MID - NIHMS360502
EDAT- 2012/06/12 06:00
MHDA- 2012/10/26 06:00
PMCR- 2013/08/01
CRDT- 2012/06/12 06:00
PHST- 2011/10/10 00:00 [received]
PHST- 2012/02/16 00:00 [revised]
PHST- 2012/02/17 00:00 [accepted]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - S0161-6420(12)00176-5 [pii]
AID - 10.1016/j.ophtha.2012.02.032 [doi]
PST - ppublish
SO  - Ophthalmology. 2012 Aug;119(8):1563-8. doi: 10.1016/j.ophtha.2012.02.032. Epub 
      2012 Jun 8.