PMID- 22683802
OWN - NLM
STAT- MEDLINE
DCOM- 20130905
LR  - 20191210
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 92
DP  - 2013 Mar
TI  - Evaluation of the brain-derived neurotrophic factor, nerve growth factor and 
      memory in adult rats survivors of the neonatal meningitis by Streptococcus 
      agalactiae.
PG  - 56-9
LID - S0361-9230(12)00106-2 [pii]
LID - 10.1016/j.brainresbull.2012.05.014 [doi]
AB  - Streptococcus agalactiae (GBS) is a major cause of severe morbidity and mortality 
      in neonates and young infants, causing sepsis, pneumonia and meningitis. The 
      survivors from this meningitis can suffer serious long-term neurological 
      consequences, such as, seizures, hearing loss, learning and memory impairments. 
      Neurotrophins, such as nerve growth factor (NGF) and brain-derived neurotrophic 
      factor (BDNF) control the neuronal cell death during the brain development and 
      play an important role in neuronal differentiation, survival and growth of 
      neurons. Neonate Wistar rats, received either 10muL of sterile saline as a placebo 
      or an equivalent volume of GBS suspension at a concentration of 1x10(6)cfu/mL. 
      Sixty days after induction of meningitis, the animals underwent behavioral tests, 
      after were killed and the hippocampus and cortex were retired for analyze of the 
      BDNF and NGF levels. In the open-field demonstrated no difference in motor, 
      exploratory activity and habituation memory between the groups. The step-down 
      inhibitory avoidance, when we evaluated the long-term memory at 24h after 
      training session, we found that the meningitis group had a decrease in aversive 
      memory when compared with the long-term memory test of the sham group. BDNF 
      levels decreased in hippocampus and cortex; however the NGF levels decreased only 
      in hippocampus. These findings suggest that the meningitis model could be a good 
      research tool for the study of the biological mechanisms involved in the 
      behavioral alterations secondary to GBS meningitis.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Barichello, Tatiana
AU  - Barichello T
AD  - Laboratorio de Microbiologia Experimental and Instituto Nacional de Ciencia e 
      Tecnologia Translacional em Medicina, Programa de Pos-Graduacao em Ciencias da 
      Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul 
      Catarinense, Criciuma, SC, Brazil. tba@unesc.net
FAU - Lemos, Joelson C
AU  - Lemos JC
FAU - Generoso, Jaqueline S
AU  - Generoso JS
FAU - Carradore, Mirelle M
AU  - Carradore MM
FAU - Moreira, Ana Paula
AU  - Moreira AP
FAU - Collodel, Allan
AU  - Collodel A
FAU - Zanatta, Jessiele R
AU  - Zanatta JR
FAU - Valvassori, Samira S
AU  - Valvassori SS
FAU - Quevedo, Joao
AU  - Quevedo J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120607
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Avoidance Learning
MH  - Brain/metabolism/microbiology/pathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Exploratory Behavior
MH  - Gene Expression Regulation
MH  - Inhibition, Psychological
MH  - Male
MH  - Memory Disorders/*etiology/microbiology
MH  - Meningitis/*complications/etiology/*metabolism/*mortality
MH  - Nerve Growth Factor/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Reaction Time
MH  - Statistics, Nonparametric
MH  - Streptococcal Infections/complications
EDAT- 2012/06/12 06:00
MHDA- 2013/09/06 06:00
CRDT- 2012/06/12 06:00
PHST- 2011/09/20 00:00 [received]
PHST- 2012/05/07 00:00 [revised]
PHST- 2012/05/25 00:00 [accepted]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2013/09/06 06:00 [medline]
AID - S0361-9230(12)00106-2 [pii]
AID - 10.1016/j.brainresbull.2012.05.014 [doi]
PST - ppublish
SO  - Brain Res Bull. 2013 Mar;92:56-9. doi: 10.1016/j.brainresbull.2012.05.014. Epub 
      2012 Jun 7.