PMID- 22684275
OWN - NLM
STAT- MEDLINE
DCOM- 20121228
LR  - 20211021
IS  - 1432-1963 (Electronic)
IS  - 0172-8113 (Linking)
VI  - 33
IP  - 4
DP  - 2012 Jul
TI  - [Role of cytology in hematopathological diagnostics].
PG  - 316-23
LID - 10.1007/s00292-012-1580-1 [doi]
AB  - The role of cytology has so far been underrecognized in the diagnostic process of 
      hematopathological questions. This article presents an algorithm which allows a 
      stepwise work-up of cytology specimens obtained by minimally invasive 
      ultrasound-guided fine needle aspiration in patients with unexplained lymph node 
      swelling. Moreover, it is shown how the selective separation of cytology 
      specimens allows the application of immunophenotypic analysis including flow 
      cytometry and immunohistochemistry as well as molecular analyses, such as 
      fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) 
      strategies. With the integrative procedure presented, cytology offers an 
      excellent cost-effective tool for the diagnostic approach of patients with 
      suspected hematopathological malignancies allowing a high diagnostic accuracy, 
      ideal for initial diagnosis or follow-up.
FAU - Bode, B
AU  - Bode B
AD  - Institut fur Klinische Pathologie, Universtitatsspital Zurich, Schmelzbergstr. 
      12, 8091, Zurich, Schweiz. beata.bode@usz.ch
FAU - Tinguely, M
AU  - Tinguely M
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Rolle der Zytologie in der hamatopathologischen Diagnostik.
PL  - Germany
TA  - Pathologe
JT  - Der Pathologe
JID - 8006541
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Algorithms
MH  - Biomarkers, Tumor/genetics
MH  - Biopsy, Fine-Needle/instrumentation/methods
MH  - Blotting, Southern/methods
MH  - Cytological Techniques/instrumentation/*methods
MH  - Diagnosis, Differential
MH  - Equipment Design
MH  - Female
MH  - Flow Cytometry/instrumentation/methods
MH  - Humans
MH  - Image-Guided Biopsy/instrumentation/methods
MH  - Immunohistochemistry/instrumentation/methods
MH  - In Situ Hybridization, Fluorescence/instrumentation/methods
MH  - Leukemia/genetics/*pathology
MH  - Lymphatic Metastasis/pathology
MH  - Lymphoma/genetics/*pathology
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction/methods
MH  - Predictive Value of Tests
MH  - Ultrasonography, Interventional/instrumentation/methods
EDAT- 2012/06/12 06:00
MHDA- 2012/12/29 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/12/29 06:00 [medline]
AID - 10.1007/s00292-012-1580-1 [doi]
PST - ppublish
SO  - Pathologe. 2012 Jul;33(4):316-23. doi: 10.1007/s00292-012-1580-1.