PMID- 22684565
OWN - NLM
STAT- MEDLINE
DCOM- 20140911
LR  - 20211021
IS  - 1672-0733 (Print)
IS  - 1672-0733 (Linking)
VI  - 32
IP  - 3
DP  - 2012 Jun
TI  - Effect of early intensive insulin therapy on immune function of aged patients 
      with severe trauma.
PG  - 400-404
LID - 10.1007/s11596-012-0069-8 [doi]
AB  - This study examined the effect of intensive insulin therapy on immune function 
      and inflammatory factors at the early phase after severe trauma. At day 1, 3, 5, 
      7 after admission, subsets of CD4(+) helper T lymphocytes (Th1/Th2) and human 
      leukocyte antigen (HLA)-DR expression on CD14(+) monocytes were flow 
      cytometrically measured. Levels of cytokines, including tumor necrosis 
      factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-10 (IL-10) and other 
      immunity markers, such as IgA, IgG, IgM, C3, C4 and C reaction protein (CRP) were 
      examined in two groups. The results showed that TNF-alpha, IL-6 and CRP levels in the 
      intensive insulin therapy group were significantly lower than those in the 
      conventional therapy group, whereas IL-10 levels were substantially increased 
      after intensive insulin therapy. C3 level at day 3, 5, 7 and C4 levels at day 5, 
      7 were lower in the intensive therapy group than in the conventional therapy 
      group. Th1/Th2 ratios decreased gradually over time in both groups, and were much 
      lower at day 3, 5, 7 in intensive therapy group. There were significant 
      differences among day 3 to day 7 after admission in HLA-DR expression in CD14(+) 
      monocytes. It was concluded that the intensive insulin therapy could decrease 
      pro-inflammatory cytokines and increase anti-inflammatory cytokines in the 
      elderly suffering from severe trauma, at the same time, with complement recovery 
      being delayed. Moreover, intensive insulin therapy promoted immune suppression 
      and, therefore, measures need be taken to address the issue.
FAU - Ma, Junxun
AU  - Ma J
AD  - Department of Emergency, the First Hospital Affiliated to the Chinese PLA General 
      Hospital, Beijing, 100048, China.
FAU - Zhao, Xiaodong
AU  - Zhao X
AD  - Department of Emergency, the First Hospital Affiliated to the Chinese PLA General 
      Hospital, Beijing, 100048, China. zxd63715@126.com.
FAU - Su, Qin
AU  - Su Q
AD  - Department of Emergency, the First Hospital Affiliated to the Chinese PLA General 
      Hospital, Beijing, 100048, China.
FAU - Dang, Wei
AU  - Dang W
AD  - Department of Emergency, the First Hospital Affiliated to the Chinese PLA General 
      Hospital, Beijing, 100048, China.
FAU - Zhang, Xian
AU  - Zhang X
AD  - Department of Emergency, the First Hospital Affiliated to the Chinese PLA General 
      Hospital, Beijing, 100048, China.
FAU - Yuan, Xiaoling
AU  - Yuan X
AD  - Department of Emergency, the First Hospital Affiliated to the Chinese PLA General 
      Hospital, Beijing, 100048, China.
FAU - Zhang, Jianbo
AU  - Zhang J
AD  - Department of Emergency, the First Hospital Affiliated to the Chinese PLA General 
      Hospital, Beijing, 100048, China.
FAU - Liu, Hongsheng
AU  - Liu H
AD  - Department of Emergency, the First Hospital Affiliated to the Chinese PLA General 
      Hospital, Beijing, 100048, China.
FAU - Qin, Yuhong
AU  - Qin Y
AD  - Department of Emergency, the First Hospital Affiliated to the Chinese PLA General 
      Hospital, Beijing, 100048, China.
FAU - Yao, Yongming
AU  - Yao Y
AD  - Department of Emergency, the First Hospital Affiliated to the Chinese PLA General 
      Hospital, Beijing, 100048, China.
FAU - Shen, Hong
AU  - Shen H
AD  - Department of Emergency, the Chinese PLA General Hospital, Beijing, 100853, 
      China.
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120609
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (Cytokines)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Immunologic Factors)
RN  - 0 (Insulin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cytokines/*immunology
MH  - Female
MH  - Humans
MH  - Hyperglycemia/*drug therapy/*immunology
MH  - Hypoglycemic Agents/therapeutic use
MH  - Immunity, Innate/drug effects/*immunology
MH  - Immunologic Factors/immunology
MH  - Insulin/*therapeutic use
MH  - Male
MH  - Treatment Outcome
MH  - Wounds and Injuries/*drug therapy/*immunology
EDAT- 2012/06/12 06:00
MHDA- 2014/09/12 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/02/07 00:00 [received]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2014/09/12 06:00 [medline]
AID - 10.1007/s11596-012-0069-8 [pii]
AID - 10.1007/s11596-012-0069-8 [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2012 Jun;32(3):400-404. doi: 
      10.1007/s11596-012-0069-8. Epub 2012 Jun 9.