PMID- 22684619
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20220408
IS  - 1613-2246 (Electronic)
IS  - 0021-5155 (Linking)
VI  - 56
IP  - 5
DP  - 2012 Sep
TI  - Reduced retinal ganglion cell complex thickness in patients with posterior 
      cerebral artery infarction detected using spectral-domain optical coherence 
      tomography.
PG  - 502-10
LID - 10.1007/s10384-012-0146-3 [doi]
AB  - PURPOSE: To report a reduction in macular ganglion cell complex (GCC) thickness 
      detected with spectral-domain optical coherence tomography (SD-OCT) in patients 
      with homonymous hemianopia following acquired cerebral damage. METHODS: We 
      analyzed case reports of three patients with unilateral posterior cerebral artery 
      (PCA) infarction. Three patients (aged 66, 68, and 71 years) with left homonymous 
      hemianopia due to infarction of the right PCA territory were studied using 
      SD-OCT. The duration of the lesions from the onset ranged from 12 to 36 months. 
      RESULTS: In all of these patients, although optic atrophy and retinal nerve fiber 
      layer defects were not detected on funduscopy, GCC thinning was demonstrated in 
      the hemiretinae corresponding to the affected hemifields. Macular GCC 
      measurements showed the localized defects of retinal ganglion cells (RGCs) more 
      clearly than circumpapillary retinal nerve fiber layer measurements. Total and 
      outer retinal thicknesses were not found to be significantly affected. 
      CONCLUSION: Our findings suggest that degeneration of RGCs can occur within a few 
      years after PCA infarction.
FAU - Yamashita, Tsutomu
AU  - Yamashita T
AD  - Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki 
      University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama 701-0193, 
      Japan.
FAU - Miki, Atsushi
AU  - Miki A
FAU - Iguchi, Yasuyuki
AU  - Iguchi Y
FAU - Kimura, Kazumi
AU  - Kimura K
FAU - Maeda, Fumiatsu
AU  - Maeda F
FAU - Kiryu, Junichi
AU  - Kiryu J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120609
PL  - Japan
TA  - Jpn J Ophthalmol
JT  - Japanese journal of ophthalmology
JID - 0044652
SB  - IM
MH  - Aged
MH  - Female
MH  - Hemianopsia/diagnosis/*etiology
MH  - Humans
MH  - Infarction, Posterior Cerebral Artery/*complications
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Fibers/*pathology
MH  - Retinal Diseases/diagnosis/*etiology
MH  - Retinal Ganglion Cells/*pathology
MH  - *Tomography, Optical Coherence
MH  - Visual Fields
EDAT- 2012/06/12 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/12 06:00
PHST- 2011/11/08 00:00 [received]
PHST- 2012/03/26 00:00 [accepted]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1007/s10384-012-0146-3 [doi]
PST - ppublish
SO  - Jpn J Ophthalmol. 2012 Sep;56(5):502-10. doi: 10.1007/s10384-012-0146-3. Epub 
      2012 Jun 9.