PMID- 22685268
OWN - NLM
STAT- MEDLINE
DCOM- 20130117
LR  - 20120822
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 14
IP  - 9
DP  - 2012 Sep
TI  - MitraClip therapy in daily clinical practice: initial results from the German 
      transcatheter mitral valve interventions (TRAMI) registry.
PG  - 1050-5
AB  - AIMS: A substantial percentage of patients with mitral regurgitation (MR) in need 
      of mitral valve repair are currently considered not suitable for conventional 
      surgery. In Germany, the largest cohort of patients studied to date has been 
      treated using a percutaneous, catheter-based approach. We report the acute 
      outcomes of patients enrolled in the investigator-initiated German transcatheter 
      mitral valve interventions (TRAMI) registry. METHODS AND RESULTS: Between January 
      2009 and August 2011, 486 patients [median age 75 (interquartile range 70-80) 
      years; 200 women (41%)] were enrolled in the registry (309 retrospectively and 
      177 prospectively), with 481 patients (99%) having undergone percutaneous 
      edge-to-edge therapy for MR using the MitraClip. At baseline, 93% of patients 
      were in New York Heart Association (NYHA) functional class III or IV and 71% of 
      patients had a left ventricular ejection fraction (LVEF) </=50%. Two-thirds of 
      patients presented with functional MR. Procedural success was achieved in 94% of 
      patients, with grade III present in 93% of patients at baseline yet only 6% 
      post-intervention. Retrospective patients were followed for a median of 183 days, 
      prospective patients for a median of 44 days. The periprocedural complication 
      rate was low, with only minor bleedings as the most significant event. 
      In-hospital and post-discharge mortality was 2.5% and 12.5%, respectively. 
      CONCLUSIONS: Data from the German TRAMI registry suggest that MitraClip therapy 
      is a viable treatment option in daily clinical routine for high surgical risk 
      patients with significant MR.
FAU - Baldus, Stephan
AU  - Baldus S
AD  - Universitares Herzzentrum Hamburg, Germany. baldus@uke.uni-hamburg.de
FAU - Schillinger, Wolfgang
AU  - Schillinger W
FAU - Franzen, Olaf
AU  - Franzen O
FAU - Bekeredjian, Raffi
AU  - Bekeredjian R
FAU - Sievert, Horst
AU  - Sievert H
FAU - Schofer, Joachim
AU  - Schofer J
FAU - Kuck, Karl-Heinz
AU  - Kuck KH
FAU - Konorza, Thomas
AU  - Konorza T
FAU - Mollmann, Helge
AU  - Mollmann H
FAU - Hehrlein, Christoph
AU  - Hehrlein C
FAU - Ouarrak, Taoufik
AU  - Ouarrak T
FAU - Senges, Jochen
AU  - Senges J
FAU - Meinertz, Thomas
AU  - Meinertz T
CN  - German Transcatheter Mitral Valve Interventions (TRAMI) investigators
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120608
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiac Catheterization/*methods
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Germany
MH  - Humans
MH  - Male
MH  - *Mitral Valve
MH  - Mitral Valve Insufficiency/mortality/physiopathology/*therapy
MH  - Patient Selection
MH  - Postoperative Complications
MH  - Prospective Studies
MH  - Registries
MH  - Retrospective Studies
MH  - *Surgical Instruments
MH  - Treatment Outcome
EDAT- 2012/06/12 06:00
MHDA- 2013/01/18 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2013/01/18 06:00 [medline]
AID - hfs079 [pii]
AID - 10.1093/eurjhf/hfs079 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2012 Sep;14(9):1050-5. doi: 10.1093/eurjhf/hfs079. Epub 2012 
      Jun 8.