PMID- 22686937
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20211021
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 67
IP  - 8
DP  - 2012 Aug
TI  - Evidence for a genetic interaction in allergy-related responsiveness to vitamin D 
      deficiency.
PG  - 1033-40
LID - 10.1111/j.1398-9995.2012.02856.x [doi]
AB  - BACKGROUND: The hormonal form of vitamin D affects both adaptive and innate 
      immune functions involved in the development of allergies. Certain genotypes have 
      been seen to alter the association between vitamin D deficiency (VDD) and the 
      risk of food sensitization in children. METHODS: We examined 27 functional single 
      nucleotide polymorphisms (SNPs) in/near selected candidate genes for association 
      with total immunoglobulin E (IgE) and effect modification by 25-hydroxyvitamin D 
      in the 1958 British birth cohort (aged 45 years, n = 4921). A cut-off value of 50 
      nmol/L was used to define VDD. RESULTS: Four SNPs (in FCER1A, IL13, and CYP24A1) 
      and three SNPs (in IL4 and CYP24A1) were associated with total IgE and specific 
      IgE, respectively, after correction for multiple testing. As in a previous study, 
      MS4A2 (rs512555, P(interaction) = 0.04) and IL4 (rs2243250, P(interaction) = 
      0.02), and their composite score (P(interaction) = 0.009) modified the 
      association between VDD and allergy-related outcome. Vitamin D deficiency was 
      associated with higher total IgE only in the carriers of the 'C' allele (IL4), 
      which is present in 86% of white Europeans, while only 26% of Chinese and <20% of 
      some African populations are carriers. CONCLUSIONS: Our study on white European 
      adults was consistent with a previous study on children from largely non-white 
      ethnic groups, suggesting that IL4 and MS4A2 genotypes modify the association 
      between VDD and allergy risk. The risk allele in IL4 is present in nearly 90% of 
      white Europeans, while less than a quarter are carriers in some other 
      populations, highlighting the need to consider possible ethnic differences in 
      allergy-related responsiveness to VDD.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Vimaleswaran, K S
AU  - Vimaleswaran KS
AD  - Centre for Paediatric Epidemiology and Biostatistics and MRC Centre for the 
      Epidemiology of Child Health, UCL Institute of Child Health, London, UK.
FAU - Cavadino, A
AU  - Cavadino A
FAU - Hypponen, E
AU  - Hypponen E
LA  - eng
GR  - G1001799/MRC_/Medical Research Council/United Kingdom
GR  - PG/09/023/BHF_/British Heart Foundation/United Kingdom
GR  - PHCS/C4/4/016/DH_/Department of Health/United Kingdom
GR  - G0400546/MRC_/Medical Research Council/United Kingdom
GR  - G0601653/MRC_/Medical Research Council/United Kingdom
GR  - PG/09/023/26806/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120612
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (MS4A2 protein, human)
RN  - 0 (Receptors, IgE)
RN  - 1406-16-2 (Vitamin D)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - A288AR3C9H (25-hydroxyvitamin D)
RN  - EC 1.14.- (Steroid Hydroxylases)
RN  - EC 1.14.15.16 (CYP24A1 protein, human)
RN  - EC 1.14.15.16 (Vitamin D3 24-Hydroxylase)
SB  - IM
MH  - Alleles
MH  - Cohort Studies
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Hypersensitivity/*genetics
MH  - Immunoglobulin E/blood/immunology
MH  - Interleukin-4/genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, IgE/genetics
MH  - Steroid Hydroxylases/genetics
MH  - Vitamin D/analogs & derivatives/blood
MH  - Vitamin D Deficiency/*genetics/*immunology
MH  - Vitamin D3 24-Hydroxylase
EDAT- 2012/06/13 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/05/07 00:00 [accepted]
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
AID - 10.1111/j.1398-9995.2012.02856.x [doi]
PST - ppublish
SO  - Allergy. 2012 Aug;67(8):1033-40. doi: 10.1111/j.1398-9995.2012.02856.x. Epub 2012 
      Jun 12.