PMID- 22687148
OWN - NLM
STAT- MEDLINE
DCOM- 20121220
LR  - 20120731
IS  - 1939-0084 (Electronic)
IS  - 0735-7044 (Linking)
VI  - 126
IP  - 4
DP  - 2012 Aug
TI  - A putative model of overeating and obesity based on brain-derived neurotrophic 
      factor: direct and indirect effects.
PG  - 505-14
LID - 10.1037/a0028600 [doi]
AB  - Increased food intake is a major contributor to the obesity epidemic in all age 
      groups. Elucidating brain systems that drive overeating and that might serve as 
      targets for novel prevention and treatment interventions is thus a high priority 
      for obesity research. The authors consider 2 major pathways by which decreased 
      activity of brain-derived neurotrophic factor (BDNF) may confer vulnerability to 
      overeating and weight gain in an obesogenic environment. The first "direct" 
      pathway focuses on the specific role of BDNF as a mediator of food intake control 
      at brain areas rich in BDNF receptors, including the hypothalamus and hindbrain. 
      It is proposed that low BDNF activity limited to this direct pathway may best 
      explain overeating and obesity outside the context of major neuropsychiatric 
      disturbance. A second "indirect" pathway considers the broad neurotrophic effects 
      of BDNF on key monoamine systems that mediate mood dysregulation, impulsivity, 
      and executive dysfunction as well as feeding behavior per se. Disruption in this 
      pathway may best explain overeating and obesity in the context of various 
      neuropsychiatric disturbances including mood disorders, attention-deficit 
      disorder, and/or binge eating disorders. An integrative model that considers 
      these potential roles of BDNF in promoting obesity is presented. The implications 
      of this model for the early prevention and treatment of obesity are also 
      considered.
FAU - Ooi, Cara L
AU  - Ooi CL
AD  - Department of Psychiatry, University of Toronto, Ontario, Canada.
FAU - Kennedy, James L
AU  - Kennedy JL
FAU - Levitan, Robert D
AU  - Levitan RD
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120611
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Appetite Regulation/genetics
MH  - Biogenic Monoamines/metabolism
MH  - Body Weight/genetics
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Feeding Behavior/physiology
MH  - Gene Expression Regulation
MH  - Humans
MH  - Hyperphagia/genetics/*metabolism/pathology
MH  - *Models, Biological
MH  - Obesity/genetics/*metabolism/pathology
EDAT- 2012/06/13 06:00
MHDA- 2012/12/21 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/12/21 06:00 [medline]
AID - 2012-15379-001 [pii]
AID - 10.1037/a0028600 [doi]
PST - ppublish
SO  - Behav Neurosci. 2012 Aug;126(4):505-14. doi: 10.1037/a0028600. Epub 2012 Jun 11.