PMID- 22687833
OWN - NLM
STAT- MEDLINE
DCOM- 20121105
LR  - 20190606
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 51
IP  - 11
DP  - 2012
TI  - Imaging findings of pancreatic cystic lesions in von Hippel-Lindau disease.
PG  - 1301-7
AB  - OBJECTIVES: The aim of this study was to characterize the pancreatic cystic 
      lesions in von Hippel-Lindau (VHL) disease and to document the changes that occur 
      in the pancreas. METHODS: We retrospectively analyzed the medical records and the 
      computed tomography (CT) and magnetic resonance imaging (MRI) findings of 20 VHL 
      patients who were diagnosed between 1996 and 2010 at our hospital. The clinical 
      findings, family history and type of tumors and/or cysts were reviewed for each 
      patient. We also analyzed the imaging findings for the pancreas in detail. 
      RESULTS: Pancreatic involvement was noted in 16 of the 20 patients (80%). Eleven 
      patients had multiple cysts diffusely distributed in the pancreas, and one 
      patient had a single cyst in the pancreas head. Two patients had serous cystic 
      neoplasms (SCNs) with multiple cysts, and another two patients had neuroendocrine 
      tumors (NETs) which were conventional radiological findings. The largest cysts of 
      four patients (26.7%) increased in size and that of three patients (20%) 
      decreased in size during the follow-up period. We performed surgical resections 
      for the pancreatic tumors (one NET and one SCN) and also performed endoscopic 
      treatment for a pancreatic cyst in one VHL patient with obstructive jaundice. 
      None of the patients died as a result of pancreatic disease. CONCLUSION: The most 
      common type of pancreatic lesions was multiple cysts. SCNs were present in only 
      10% of the VHL patients. Pancreatic cysts showed positive and/or negative growth 
      according to the CT and MRI findings. The pancreatic cystic lesions did not 
      influence the outcome of the VHL patients.
FAU - Kobayashi, Noritoshi
AU  - Kobayashi N
AD  - Gastroenterology Division, Yokohama City University Graduate School of Medicine, 
      Japan. norikoba@yokohama-cu.ac.jp
FAU - Sato, Takamitsu
AU  - Sato T
FAU - Kato, Shingo
AU  - Kato S
FAU - Watanabe, Seitaro
AU  - Watanabe S
FAU - Hosono, Kunihiro
AU  - Hosono K
FAU - Shimamura, Takeshi
AU  - Shimamura T
FAU - Iida, Hiroshi
AU  - Iida H
FAU - Endo, Hiroki
AU  - Endo H
FAU - Koide, Tomoko
AU  - Koide T
FAU - Takahashi, Hirokazu
AU  - Takahashi H
FAU - Yoneda, Masato
AU  - Yoneda M
FAU - Shibata, Wataru
AU  - Shibata W
FAU - Abe, Yasunobu
AU  - Abe Y
FAU - Inamori, Masahiko
AU  - Inamori M
FAU - Kirikoshi, Hiroyuki
AU  - Kirikoshi H
FAU - Saito, Satoru
AU  - Saito S
FAU - Maeda, Shin
AU  - Maeda S
FAU - Nakajima, Atsushi
AU  - Nakajima A
FAU - Kubota, Kensuke
AU  - Kubota K
LA  - eng
PT  - Journal Article
DEP - 20120601
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Pancreatic Cyst/diagnostic imaging/*pathology
MH  - Retrospective Studies
MH  - Time Factors
MH  - Tomography, X-Ray Computed
MH  - von Hippel-Lindau Disease/diagnostic imaging/*pathology
EDAT- 2012/06/13 06:00
MHDA- 2012/11/06 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/11/06 06:00 [medline]
AID - DN/JST.JSTAGE/internalmedicine/51.7194 [pii]
AID - 10.2169/internalmedicine.51.7194 [doi]
PST - ppublish
SO  - Intern Med. 2012;51(11):1301-7. doi: 10.2169/internalmedicine.51.7194. Epub 2012 
      Jun 1.