PMID- 22687996
OWN - NLM
STAT- MEDLINE
DCOM- 20121018
LR  - 20190911
IS  - 1880-3989 (Electronic)
IS  - 0388-1350 (Linking)
VI  - 37
IP  - 3
DP  - 2012
TI  - Lack of effects for dietary exposure of bisphenol A during in utero and 
      lactational periods on reproductive development in rat offspring.
PG  - 565-73
AB  - The potential for health effects on humans with exposure to bisphenol A (BPA) has 
      raised concerns, and the adverse effects of low-dose exposure to BPA on 
      reproduction have been controversial. The purpose of the present study was to 
      investigate the effects of low-dose exposure to BPA on reproductive development 
      in F(1) rat offspring. Pregnant female Sprague-Dawley rats (F(0)) were fed a diet 
      containing low doses of BPA (0, 0.33, 3.3, or 33 ppm) from gestational day (GD) 6 
      through postnatal day (PND) 21. The weanlings (F(1)) from all dose groups were 
      fed a normal diet ad libitum after weaning and then were subjected to necropsy at 
      5 weeks or 3 months of age. No BPA-related changes were observed in body weight 
      or weight of any of the major reproductive organs in F(1) males and females. 
      Epididymis weight was significantly lower only in 3-month-old F(1) males exposed 
      to 33 ppm BPA. Anogenital distance (AGD), the ratio of AGD to the cube root of 
      body weight, and relative ovary weight were significantly lower in 5-week-old 
      F(1) females exposed to 3.3 and 33 ppm BPA, but significant differences were not 
      observed in 3-month-old females. There were no BPA-related effects on cauda 
      epididymal sperm motility in 3-month-old F(1) males. Plasma reproductive steroid 
      hormone concentrations were not altered among groups in either sex. These 
      outcomes indicate that low-dose exposure to BPA in the diet does not adversely 
      affect reproductive development in F(1) rat offspring.
FAU - Kobayashi, Kenichi
AU  - Kobayashi K
AD  - National Institute of Occupational Safety and Health, Kawasaki, Japan. 
      kobayasi@h.jniosh.go.jp
FAU - Kubota, Hisayo
AU  - Kubota H
FAU - Ohtani, Katsumi
AU  - Ohtani K
FAU - Hojo, Rieko
AU  - Hojo R
FAU - Miyagawa, Muneyuki
AU  - Miyagawa M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Hormones)
RN  - 0 (Phenols)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Benzhydryl Compounds
MH  - Body Weight/drug effects
MH  - Diet
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Genitalia/*drug effects/*growth & development
MH  - Hormones/analysis/metabolism
MH  - Lactation
MH  - Male
MH  - Organ Size
MH  - Phenols/*toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reproduction/*drug effects
MH  - Sperm Motility/drug effects
MH  - Weaning
EDAT- 2012/06/13 06:00
MHDA- 2012/10/19 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/10/19 06:00 [medline]
AID - DN/JST.JSTAGE/jts/37.565 [pii]
AID - 10.2131/jts.37.565 [doi]
PST - ppublish
SO  - J Toxicol Sci. 2012;37(3):565-73. doi: 10.2131/jts.37.565.