PMID- 2268979
OWN - NLM
STAT- MEDLINE
DCOM- 19910219
LR  - 20061115
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 34
IP  - 5
DP  - 1990 Nov
TI  - Interstitial cellular infiltration detected by fine-needle aspiration biopsy in 
      nephritis.
PG  - 189-96
AB  - Fine-needle aspiration biopsy (FNAB) was used to detect renal mononuclear 
      interstitial inflammation in 56 patients with various types of nephritis (20 IgA 
      nephropathy, 8 focal necrotizing glomerulonephritis, 7 interstitial nephritis, 6 
      non-classifiable chronic glomerulonephritis, 5 mesangial proliferative (non-IgA) 
      chronic glomerulonephritis, 4 focal glomerulosclerosis, 6 normal histology, who 
      were examined for microscopic hematuria, and 7 controls). Regular renal biopsies 
      for histological and immunofluorescence studies were simultaneously obtained, and 
      available for comparative analysis (not controls). Differential counts of 
      mononuclear infiltration and subtyping of T-cell infiltration into T-helper (T-h) 
      and T-suppressor-cytotoxic (T-s-c) cells, as detected by immunoperoxidase stains 
      from FNAB, were correlated to clinical manifestations and renal function tests. 
      Generally, our results indicated increased mononuclear cell infiltration 
      (monocytes, lymphocytes, and/or activated lymphocytes) in FNAB of patients with 
      IgA nephropathy, interstitial nephritis or focal necrotizing glomerulonephritis 
      (especially monocytes in IgA nephropathy and interstitial nephritis, p less than 
      0.05 compared with controls, lymphocytes in focal necrotizing glomerulonephritis, 
      and non-classifiable glomerulonephritis, p less than 0.02 and 0.05, 
      respectively). The number of infiltrating activated lymphocytes was significantly 
      increased in focal necrotizing glomerulonephritis, interstitial nephritis and 
      focal glomerulosclerosis, p less than 0.05, less than 0.01 and less than 0.01, 
      respectively. FNAB was at least as sensitive as histological examination for the 
      quantification of interstitial cellular infiltration, and it allowed for 
      cytological differential counts. Patients had decreased T-h and increased T-s-c 
      cell counts, which were accentuated in FNAB compared with peripheral blood, 
      although there were strong positive correlations between local and peripheral 
      counts (p less than 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Gronhagen-Riska, C
AU  - Gronhagen-Riska C
AD  - IVth Department of Medicine, Helsinki University Central Hospital, Finland.
FAU - von Willebrand, E
AU  - von Willebrand E
FAU - Honkanen, E
AU  - Honkanen E
FAU - Laasonen, L
AU  - Laasonen L
FAU - Tornroth, T
AU  - Tornroth T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
SB  - IM
MH  - Adult
MH  - Biopsy, Needle
MH  - Female
MH  - Glomerulonephritis/*pathology
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Kidney/*pathology
MH  - Leukocytes, Mononuclear/pathology
MH  - Male
MH  - Nephritis, Interstitial/*pathology
MH  - T-Lymphocyte Subsets/pathology
EDAT- 1990/11/01 00:00
MHDA- 1990/11/01 00:01
CRDT- 1990/11/01 00:00
PHST- 1990/11/01 00:00 [pubmed]
PHST- 1990/11/01 00:01 [medline]
PHST- 1990/11/01 00:00 [entrez]
PST - ppublish
SO  - Clin Nephrol. 1990 Nov;34(5):189-96.