PMID- 22690067
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20211021
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 18
IP  - 21
DP  - 2012 Jun 7
TI  - Motor vehicle accidents: how should cirrhotic patients be managed?
PG  - 2597-9
LID - 10.3748/wjg.v18.i21.2597 [doi]
AB  - Motor vehicle accidents (MVAs) are serious social issues worldwide and driver 
      illness is an important cause of MVAs. Minimal hepatic encephalopathy (MHE) is a 
      complex cognitive dysfunction with attention deficit, which frequently occurs in 
      cirrhotic patients independent of severity of liver disease. Although MHE is 
      known as a risk factor for MVAs, the impact of diagnosis and treatment of MHE on 
      MVA-related societal costs is largely unknown. Recently, Bajaj et al demonstrated 
      valuable findings that the diagnosis of MHE by rapid screening using the 
      inhibitory control test (ICT), and subsequent treatment with lactulose could 
      substantially reduce the societal costs by preventing MVAs. Besides the ICT and 
      lactulose, there are various diagnostic tools and therapeutic strategies for MHE. 
      In this commentary, we discussed a current issue of diagnostic tools for MHE, 
      including neuropsychological tests. We also discussed the advantages of the other 
      therapeutic strategies for MHE, such as intake of a regular breakfast and coffee, 
      and supplementation with zinc and branched chain amino acids, on the MVA-related 
      societal costs.
FAU - Kawaguchi, Takumi
AU  - Kawaguchi T
AD  - Division of Gastroenterology, Department of Medicine, Kurume University School of 
      Medicine, Kurume 830-0011, Japan. takumi@med.kurume-u.ac.jp
FAU - Taniguchi, Eitaro
AU  - Taniguchi E
FAU - Sata, Michio
AU  - Sata M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Amino Acids, Branched-Chain)
RN  - 0 (Coffee)
RN  - 4618-18-2 (Lactulose)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Accidents, Traffic/*prevention & control
MH  - Algorithms
MH  - Amino Acids, Branched-Chain/therapeutic use
MH  - Coffee
MH  - Cognition
MH  - Cognition Disorders/therapy
MH  - Fibrosis/*complications/*therapy
MH  - Hepatic Encephalopathy/complications/diagnosis
MH  - Humans
MH  - Lactulose/therapeutic use
MH  - Neuropsychological Tests
MH  - Psychometrics
MH  - Risk Factors
MH  - Treatment Outcome
MH  - Wounds and Injuries/*prevention & control
MH  - Zinc/therapeutic use
PMC - PMC3369995
OTO - NOTNLM
OT  - Branched chain amino acids
OT  - Coffee
OT  - Subclinical hepatic encephalopathy
OT  - Traffic accident
OT  - Zinc
EDAT- 2012/06/13 06:00
MHDA- 2012/10/30 06:00
PMCR- 2012/06/07
CRDT- 2012/06/13 06:00
PHST- 2012/05/11 00:00 [received]
PHST- 2012/05/18 00:00 [revised]
PHST- 2012/05/23 00:00 [accepted]
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
PHST- 2012/06/07 00:00 [pmc-release]
AID - 10.3748/wjg.v18.i21.2597 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2012 Jun 7;18(21):2597-9. doi: 10.3748/wjg.v18.i21.2597.