PMID- 22691100
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20120613
IS  - 1557-8976 (Electronic)
IS  - 0882-8245 (Linking)
VI  - 25
IP  - 3
DP  - 2012 Jun
TI  - HLA-DRB1-DQA1-DQB1 genotype and frequency of enterovirus in longitudinal monthly 
      fecal samples from healthy infants.
PG  - 187-92
LID - 10.1089/vim.2012.0001 [doi]
AB  - Enterovirus infections may be involved in the etiology of type 1 diabetes (T1D), 
      which is strongly associated with certain human leukocyte antigen (HLA) class II 
      haplotypes. Our aim was to assess whether HLA genotypes conferring varying 
      degrees of risk for T1D were associated with enterovirus gut infections. From the 
      general Norwegian population, 190 healthy infants at high-risk for T1D 
      (DR4-DQ8/DR3-DQ2), and 383 infants without this genotype were identified. 
      Non-DR4-DQ8/DR3-DQ2 genotypes were further categorized as conferring either an 
      increased-to-moderate risk (DR4-DQ8 or DR3-DQ2), were protective (DQB1*06:02), or 
      were neutral (all other genotypes). A total of 4626 monthly fecal samples taken 
      between age 3 and 12 mo were tested for enterovirus RNA using real-time PCR. 
      Enterovirus prevalence was 11.5% among high-risk children, and 12.2% in other 
      children (adjusted odds ratio: 1.23, p=0.12). The prevalence was 11.3% in those 
      with increased-to-moderate risk, 13.0% in the protective group, and 12.6% in the 
      neutral group (likelihood ratio test, 3 d.f.: p=0.37). In conclusion, there was 
      no statistically significant association between HLA genotype and the occurrence 
      of human enterovirus gut infections.
FAU - Witso, Elisabet
AU  - Witso E
AD  - Norwegian Institute of Public Health, Postboks 4404 Nydalen, 0403 Oslo, Norway. 
      elisabet.witso@fhi.no
FAU - Cinek, Ondrej
AU  - Cinek O
FAU - Tapia, German
AU  - Tapia G
FAU - Rasmussen, Trond
AU  - Rasmussen T
FAU - Stene, Lars C
AU  - Stene LC
FAU - Ronningen, Kjersti S
AU  - Ronningen KS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Viral Immunol
JT  - Viral immunology
JID - 8801552
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Diabetes Mellitus, Type 1/genetics/virology
MH  - Enterovirus/genetics/*isolation & purification
MH  - Enterovirus Infections/*epidemiology/genetics/virology
MH  - Feces/*virology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ alpha-Chains/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Infant
MH  - Male
EDAT- 2012/06/14 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/06/14 06:00
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/06/14 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - 10.1089/vim.2012.0001 [doi]
PST - ppublish
SO  - Viral Immunol. 2012 Jun;25(3):187-92. doi: 10.1089/vim.2012.0001.