PMID- 22691211
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20221207
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 30
IP  - 2 Suppl 71
DP  - 2012 Mar-Apr
TI  - Prevalence and clinical importance of gastroesophageal reflux in Chinese patients 
      with systemic sclerosis.
PG  - S60-6
AB  - OBJECTIVES: To estimate the prevalence of gastroesophageal reflux (GER) and its 
      clinical relevance with other manifestations in Chinese patients with systemic 
      sclerosis (SSc). METHODS: A prospective cross-sectional study of 205 Chinese 
      patients with SSc was conducted at Peking Union Medical College Hospital (PUMCH). 
      GER was diagnosed as mild heartburn or regurgitation >/=2 days per week, or 
      moderate/severe heartburn or regurgitation >/=1 day a week. PAH was defined as 
      pulmonary artery systolic pressure (PASP) >45mmHg at rest as estimated by 
      transthoracic echocardiography (TTE). Demographic, clinical, and laboratory data 
      were calculated between GER and non-GER groups, and relative examinations 
      including a six-minute walk test, pulmonary function test and modified Rodnan 
      skin score (mRSS) were also performed. RESULTS: The prevalence of GER was 43.90% 
      (90/205) among 205 Chinese patients with SSc. The presence of Raynaud phenomenon 
      (98.9% vs. 92.2%), fingertip ulcers (56.7% vs. 51.3%), pulmonary arterial 
      hypertension (PAH) (18.89% vs. 6.96%, respectively), and all gastrointestinal 
      tract manifestations occurred significantly more frequent in patients with GER 
      than in patients without GER, respectively (p<0.05). There were no differences in 
      the development of any autoantibody between GER patients and non-GER patients 
      (p>0.05). Echocardiography showed that the left ventricular ejection fraction 
      (LVEF) was lower (62.27+/-10.48 vs. 70.09+/-5.26, respectively) and pericarditis was 
      more frequent (22.6% vs. 11.0%, respectively) in SSc-related GER than in SSc 
      patients without GER, respectively. The New York Heart Association (NYHA) 
      functional class of SSc-related GER was worse than patients without GER 
      (p=0.015). A pulmonary function test showed that forced vital capacity FVC% 
      (78.93+/-17.90 vs. 84.55+/-17.45, respectively, p=0.042), forced expiratory volume 
      FEV1% (77.12+/-15.65 vs. 84.30+/-16.25, respectively, p=0.004), and diffusing 
      capacity DLCO% (4.76+/-1.76 vs. 5.63+/-2.12, respectively, p<0.001) were lower, and 
      the FVC%/DLCO% ratio (1.46+/-0.42 vs. 1.28+/-0.27, respectively, p=0.001)was higher 
      in SSc-related GER than non-GER patients (p<0.05). We also found that GER was an 
      independent risk factor of PAH in SSc patients (p=0.030, OR=7.532). CONCLUSIONS: 
      GER is common in Chinese patients with SSc, and patients with GER are susceptible 
      to microvascular damage. Therefore, SSc patients presenting with GER should be 
      screened for PAH.
FAU - Liu, Xinjuan
AU  - Liu X
AD  - Department of Rheumatology, Chinese Academy of Medical Science, Beijing, China. 
      lxjw2009@gmail.com
FAU - Li, Mengtao
AU  - Li M
FAU - Xu, Dong
AU  - Xu D
FAU - Hou, Yong
AU  - Hou Y
FAU - Wang, Qian
AU  - Wang Q
FAU - Tian, Zhuang
AU  - Tian Z
FAU - Sun, Qiuning
AU  - Sun Q
FAU - Zeng, Xiaofeng
AU  - Zeng X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120530
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian People/*statistics & numerical data
MH  - Chi-Square Distribution
MH  - Child
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Familial Primary Pulmonary Hypertension
MH  - Female
MH  - Gastroesophageal Reflux/diagnosis/*ethnology
MH  - Humans
MH  - Hypertension, Pulmonary/ethnology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Scleroderma, Systemic/diagnosis/*ethnology
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2012/07/26 06:00
MHDA- 2012/08/14 06:00
CRDT- 2012/06/14 06:00
PHST- 2011/11/30 00:00 [received]
PHST- 2012/02/01 00:00 [accepted]
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - 5635 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2012 Mar-Apr;30(2 Suppl 71):S60-6. Epub 2012 May 30.