PMID- 22692317
OWN - NLM
STAT- MEDLINE
DCOM- 20130926
LR  - 20171116
IS  - 1671-167X (Print)
IS  - 1671-167X (Linking)
VI  - 44
IP  - 3
DP  - 2012 Jun 18
TI  - [Protective effect of exogenous nucleotides on the developmental toxicity of 
      alcohol].
PG  - 426-30
AB  - OBJECTIVE: To investigate the preventive effect of exogenous nucleotide (EN) on 
      the developmental toxicity of alcohol. METHODS: C57BL/6J pregnant mice were 
      divided into 6 groups randomly: the control group, the alcohol group, the low 
      (0.01%EN), middle (0.04%EN), high (0.16%EN) and higher (0.64% EN) intervention 
      groups. From the 6th gestational days (GD) to the 15th GD, pregnant animals 
      except those in the control group were administrated with 5 g (per kg body 
      weight) alcohol intragastrically. Normal mouse forage was provided to the animals 
      in the control group and alcohol group, while forage containing different 
      quantities of EN was provided to the animals in the intervention groups. On GD 
      18, all the dams were killed, their blood samples were collected for further 
      analysis, and fetal developmental indexes were observed. RESULTS: Compared with 
      the animals in the alcohol group, offspring's body weight and placenta weight of 
      EN intervention groups improved a lot; superoxide dismutase (SOD) and glutathione 
      peroxidase (GSH-Px) activity increased significantly (P<0.05), malondialdehyde 
      (MDA) levels decreased significantly (P<0.01); the live birth rate of animals in 
      the interventions groups has increased significantly and the absorbed embryo rate 
      of them has decreased significantly (P<0.01); the forepaw phalanges, hindpaw 
      phalanges and caudal vertebrae ossification point increased significantly 
      (P<0.01); the anomalies of both occipital and sternum have decreased 
      significantly in 0.04%EN group (P<0.05). CONCLUSION: EN has a significant 
      protective effect on the developmental toxicity of alcohol.
FAU - Dong, Wen-hong
AU  - Dong WH
AD  - Department of Nutrition and Food Hygiene, Peking University School of Public 
      Health, Beijing, China.
FAU - Zhao, Jie
AU  - Zhao J
FAU - Zhang, Jia-xi
AU  - Zhang JX
FAU - Xu, Lin-lin
AU  - Xu LL
FAU - Xu, Ya-jun
AU  - Xu YJ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Beijing Da Xue Xue Bao Yi Xue Ban
JT  - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health 
      sciences
JID - 101125284
RN  - 0 (Nucleotides)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Ethanol/*toxicity
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/*prevention & control
MH  - Male
MH  - *Maternal Exposure
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nucleotides/pharmacology/*therapeutic use
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*prevention & control
EDAT- 2012/06/14 06:00
MHDA- 2013/09/27 06:00
CRDT- 2012/06/14 06:00
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/06/14 06:00 [pubmed]
PHST- 2013/09/27 06:00 [medline]
PST - ppublish
SO  - Beijing Da Xue Xue Bao Yi Xue Ban. 2012 Jun 18;44(3):426-30.