PMID- 22692935
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20120709
IS  - 1558-0210 (Electronic)
IS  - 1534-4320 (Linking)
VI  - 20
IP  - 4
DP  - 2012 Jul
TI  - A closed loop feedback system for automatic detection and inhibition of 
      mechano-nociceptive neural activity.
PG  - 478-87
LID - 10.1109/TNSRE.2012.2197220 [doi]
AB  - Clinical studies have shown that spinal or cerebral neurostimulation can 
      significantly relieve pain. Current neurostimulators work in an open loop; hence, 
      their efficacy depends on the patient's or physician's comprehension of pain. We 
      have proposed and developed a real-time automatic recognition program with signal 
      processing functions to detect action potentials. By using a wireless 
      neurorecording module, spinal neuronal responses to mechanical stimuli (brush, 
      pressure, and pinch) applied to rats' hind paws were recorded. Nociceptive spinal 
      responses were detected and suppressed by our automated module through delivering 
      electrical stimulation to the periaqueductal gray (PAG). The interspike intervals 
      (ISIs) of the fired action potentials were used to distinguish among the three 
      different mechanical stimuli. Our system was able to detect the neuronal activity 
      intensities and deliver trigger signals to the neurostimulator according to a 
      pre-set threshold in a closed-loop feedback configuration, thereby suppressing 
      excessive activity in spinal cord dorsal horn neurons.
FAU - Farajidavar, Aydin
AU  - Farajidavar A
AD  - Department of Bioengineering, University of Texas at Arlington, Arlington, TX 
      76019, USA. aydin1@ece.gatech.edu
FAU - Hagains, Christopher E
AU  - Hagains CE
FAU - Peng, Yuan B
AU  - Peng YB
FAU - Chiao, J-C
AU  - Chiao JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120605
PL  - United States
TA  - IEEE Trans Neural Syst Rehabil Eng
JT  - IEEE transactions on neural systems and rehabilitation engineering : a 
      publication of the IEEE Engineering in Medicine and Biology Society
JID - 101097023
SB  - IM
MH  - Action Potentials
MH  - Animals
MH  - Biofeedback, Psychology/*instrumentation
MH  - Electric Stimulation Therapy/*instrumentation
MH  - Equipment Design
MH  - Equipment Failure Analysis
MH  - Male
MH  - Nociceptive Pain/*physiopathology/prevention & control
MH  - *Prostheses and Implants
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord/*physiology
MH  - Telemetry/instrumentation
MH  - Therapy, Computer-Assisted/*methods
MH  - *Touch
EDAT- 2012/06/14 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/14 06:00
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/06/14 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1109/TNSRE.2012.2197220 [doi]
PST - ppublish
SO  - IEEE Trans Neural Syst Rehabil Eng. 2012 Jul;20(4):478-87. doi: 
      10.1109/TNSRE.2012.2197220. Epub 2012 Jun 5.