PMID- 22694150
OWN - NLM
STAT- MEDLINE
DCOM- 20130619
LR  - 20131121
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 36
IP  - 5
DP  - 2012 Sep
TI  - Differential modulation of motor cortex excitability in BDNF Met allele carriers 
      following experimentally induced and use-dependent plasticity.
PG  - 2640-9
LID - 10.1111/j.1460-9568.2012.08177.x [doi]
AB  - The purpose of this study was to investigate how healthy young subjects with one 
      of three variants of the brain-derived neurotrophic factor (BDNF) gene modulate 
      motor cortex excitability following experimentally induced and use-dependent 
      plasticity interventions. Electromyographic recordings were obtained from the 
      right first dorsal interosseous (FDI) muscle of 12 Val/Val, ten Val/Met and seven 
      Met/Met genotypes (aged 18-39 years). Transcranial magnetic stimulation of the 
      left hemisphere was used to assess changes in FDI motor-evoked potentials (MEPs) 
      following three separate interventions involving paired associative stimulation, 
      a simple ballistic task and complex visuomotor tracking task using the index 
      finger. Val/Val subjects increased FDI MEPs following all interventions (>/= 25%, P 
      < 0.01), whereas the Met allele carriers only showed increased MEPs after the 
      simple motor task (>/= 26%, P < 0.01). In contrast to the simple motor task, there 
      was no significant change in MEPs for the Val/Met subjects (7%, P = 0.50) and a 
      reduction in MEPs for the Met/Met group (-38%, P < 0.01) following the complex 
      motor task. Despite these differences in use-dependent plasticity, the 
      performance of both motor tasks was not different between BDNF genotypes. We 
      conclude that modulation of motor cortex excitability is strongly influenced by 
      the BDNF polymorphism, with the greatest differences observed for the complex 
      motor task. We also found unique motor cortex plasticity in the rarest form of 
      the BDNF polymorphism (Met/Met subjects), which may have implications for 
      functional recovery after disease or injury to the nervous system in these 
      individuals.
CI  - (c) 2012 The Authors. European Journal of Neuroscience (c) 2012 Federation of 
      European Neuroscience Societies and Blackwell Publishing Ltd.
FAU - Cirillo, John
AU  - Cirillo J
AD  - Discipline of Physiology, School of Medical Sciences, The University of Adelaide, 
      Adelaide, SA, Australia.
FAU - Hughes, James
AU  - Hughes J
FAU - Ridding, Michael
AU  - Ridding M
FAU - Thomas, Paul Q
AU  - Thomas PQ
FAU - Semmler, John G
AU  - Semmler JG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120613
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics/physiology
MH  - Evoked Potentials, Motor/genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Motor Cortex/*physiology
MH  - Neuronal Plasticity/*genetics
MH  - Polymorphism, Genetic
EDAT- 2012/06/15 06:00
MHDA- 2013/06/20 06:00
CRDT- 2012/06/15 06:00
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2013/06/20 06:00 [medline]
AID - 10.1111/j.1460-9568.2012.08177.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2012 Sep;36(5):2640-9. doi: 10.1111/j.1460-9568.2012.08177.x. 
      Epub 2012 Jun 13.