PMID- 22694907
OWN - NLM
STAT- MEDLINE
DCOM- 20130529
LR  - 20181201
IS  - 1879-0593 (Electronic)
IS  - 1368-8375 (Linking)
VI  - 48
IP  - 10
DP  - 2012 Oct
TI  - Epidermal growth factor receptor (EGFR) in salivary gland carcinomas: potentials 
      as therapeutic target.
PG  - 991-996
LID - S1368-8375(12)00160-1 [pii]
LID - 10.1016/j.oraloncology.2012.05.005 [doi]
AB  - AIMS: Epidermal growth factor (EGFR) is involved in angiogenesis, cell 
      differentiation, proliferation and progression of many cancers and is an 
      important therapy target in lung and colorectal cancer. To determine the 
      potential applicability of EGFR targeted therapies, EGFR status of over 800 
      salivary gland tumors of different entities were analyzed on DNA and protein 
      level by FISH and IHC. MATERIALS AND METHODS: A tissue microarray was constructed 
      from 721 carcinomas and 205 adenomas of the salivary gland. EGFR expression and 
      EGFR gene copy number was assessed by means of immunohistochemistry and 
      fluorescence in situ hybridization (FISH). EGFR mutation analysis of exon 19 and 
      21 was performed in a subset of 107 carcinomas. RESULTS: Positive 
      immunohistochemical staining (definition?) for EGFR was shown in 324 of 663 
      (48.9%) salivary gland carcinomas. The frequency was dependent on the tumor 
      entity and ranged from 17.9% (30 of 168 cases) positive immunostaining in acinic 
      cell adenocarcinomas to 85.7% (42 of 49 cases) in Warthin tumors. No EGFR 
      amplification was found by FISH. EGFR mutation analysis of Exon 19 and 21 in 107 
      salivary gland carcinomas revealed mutations in two acinic cell adenocarcinomas. 
      CONCLUSION: EGFR protein expression is common in salivary gland tumors but is not 
      associated with gene amplification. Activating mutations of EGFR are rare. 
      Nonetheless, selected cases of patients with salivary gland carcinomas might 
      potentially benefit of anti-EGFR therapy.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Clauditz, Till Sebastian
AU  - Clauditz TS
AD  - Institute of Pathology, Hubertus-Wald-Cancer-Center, University Medical Center 
      Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. Electronic address: 
      t.clauditz@uke.de.
FAU - Gontarewicz, Artur
AU  - Gontarewicz A
AD  - Institute of Pathology, Hubertus-Wald-Cancer-Center, University Medical Center 
      Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
FAU - Lebok, Patrick
AU  - Lebok P
AD  - Institute of Pathology, Hubertus-Wald-Cancer-Center, University Medical Center 
      Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
FAU - Tsourlakis, Maria-Christina
AU  - Tsourlakis MC
AD  - Institute of Pathology, Hubertus-Wald-Cancer-Center, University Medical Center 
      Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
FAU - Grob, Tobias J
AU  - Grob TJ
AD  - Institute of Pathology, Hubertus-Wald-Cancer-Center, University Medical Center 
      Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
FAU - Munscher, Adrian
AU  - Munscher A
AD  - Department of Otolaryngology, Head and Neck Surgery, Hubertus-Wald-Cancer-Center, 
      University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, 
      Germany.
FAU - Sauter, Guido
AU  - Sauter G
AD  - Institute of Pathology, Hubertus-Wald-Cancer-Center, University Medical Center 
      Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
FAU - Bokemeyer, Carsten
AU  - Bokemeyer C
AD  - Department of Oncology, Haematology, Bone Marrow Transplantation and Section 
      Pneumology, Hubertus-Wald-Cancer-Center, University Medical Center 
      Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
FAU - Knecht, Rainald
AU  - Knecht R
AD  - Department of Otolaryngology, Head and Neck Surgery, Hubertus-Wald-Cancer-Center, 
      University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, 
      Germany.
FAU - Wilczak, Waldemar
AU  - Wilczak W
AD  - Institute of Pathology, Hubertus-Wald-Cancer-Center, University Medical Center 
      Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20120612
PL  - England
TA  - Oral Oncol
JT  - Oral oncology
JID - 9709118
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adenoma/genetics/*metabolism
MH  - Biomarkers, Tumor/genetics/metabolism
MH  - Carcinoma/genetics/*metabolism
MH  - ErbB Receptors/genetics/*metabolism
MH  - Exons
MH  - Female
MH  - Gene Amplification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Mutation
MH  - Salivary Gland Neoplasms/genetics/*metabolism
EDAT- 2012/06/15 06:00
MHDA- 2013/05/31 06:00
CRDT- 2012/06/15 06:00
PHST- 2012/03/30 00:00 [received]
PHST- 2012/05/02 00:00 [accepted]
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2013/05/31 06:00 [medline]
AID - S1368-8375(12)00160-1 [pii]
AID - 10.1016/j.oraloncology.2012.05.005 [doi]
PST - ppublish
SO  - Oral Oncol. 2012 Oct;48(10):991-996. doi: 10.1016/j.oraloncology.2012.05.005. 
      Epub 2012 Jun 12.