PMID- 22695270
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20220331
IS  - 1872-6968 (Electronic)
IS  - 0303-8467 (Linking)
VI  - 115
IP  - 3
DP  - 2013 Mar
TI  - Influence of multisystemic affection on health-related quality of life in 
      patients with myotonic dystrophy type 1.
PG  - 270-5
LID - S0303-8467(12)00275-2 [pii]
LID - 10.1016/j.clineuro.2012.05.015 [doi]
AB  - AIM: To assess health-related quality of life (HRQoL) in patients with DM1, to 
      identify muscular, multisystemic, central and social factors that may affect QoL 
      and to define a DM1 patient in risk of poor QoL. PATIENTS AND METHOD: This 
      cross-sectional study comprised 120 DM1 consecutive patients. The following 
      scales were used: Multidimensional Scale of Perceived Social Support (MSPSS), 
      Muscular Impairment Rating Scale (MIRS), battery of neuropsychological tests, 
      acceptance of illness scale (AIS), Hamilton rating scale for depression (Ham-D), 
      Krupp's Fatigue Severity Scale (FSS), Daytime Sleepiness Scale (DSS) and SF-36 
      questionnaire. RESULTS: HRQoL was impaired in DM1 patients in both physical and 
      mental domains (PCS was 41.8+/-23.5, MCS 47.0+/-24.3 and total SF-36 score 
      45.6+/-24.0). The most significant factors correlating with better SF-36 total 
      score were younger age (beta=-0.45, p<0.001), shorter duration of disease (beta=-0.27, 
      p=0.001), higher education (beta=0.20, p=0.009), less severe muscular weakness 
      (beta=-0.52, p<0.001), normal swallowing (beta=0.22, p=0.005), absence of fainting 
      (beta=0.31, p=0.002), absence of snoring (beta=0.21, p=0.036), better acceptance of 
      disease (beta=-0.17, p=0.036), lower depressiveness (beta=-0.46, p=0.001), lower 
      fatigue (beta=-0.32, p=0.001), absence of cataract (beta=-0.21, p=0.034), absence of 
      kyphosis (beta=0.31, p=0.004) and absence of constipation (beta=0.24, p=0.016). Second 
      linear regression analysis revealed that depressed (beta=-0.38, p<0.001) and elder 
      patients (beta=-0.27, p=0.007) and as well as those with poor acceptance of illness 
      (beta=-0.21, p=0.006) were in especially higher risk of having poor HRQoL 
      (R(2)=0.68). CONCLUSION: We identified different central, social, muscular, 
      cardiorespiratory and other factors correlating with HRQoL. It is of great 
      importance that most of these factors are amenable to treatment.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Peric, S
AU  - Peric S
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia. stojanperic@gmail.com
FAU - Stojanovic, V Rakocevic
AU  - Stojanovic VR
FAU - Basta, I
AU  - Basta I
FAU - Peric, M
AU  - Peric M
FAU - Milicev, M
AU  - Milicev M
FAU - Pavlovic, S
AU  - Pavlovic S
FAU - Lavrnic, D
AU  - Lavrnic D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120612
PL  - Netherlands
TA  - Clin Neurol Neurosurg
JT  - Clinical neurology and neurosurgery
JID - 7502039
SB  - IM
MH  - Adult
MH  - Central Nervous System/physiopathology
MH  - Cognition Disorders/etiology/psychology
MH  - Cross-Sectional Studies
MH  - Depression/complications/psychology
MH  - Educational Status
MH  - Electromyography
MH  - Fatigue/complications/psychology
MH  - Female
MH  - Heart/physiopathology
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Marital Status
MH  - Middle Aged
MH  - Muscle, Skeletal/physiopathology
MH  - Myotonic Dystrophy/*physiopathology/*psychology
MH  - Neuropsychological Tests
MH  - Occupations
MH  - *Quality of Life
MH  - Respiratory System/physiopathology
MH  - Risk
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
EDAT- 2012/06/15 06:00
MHDA- 2013/07/23 06:00
CRDT- 2012/06/15 06:00
PHST- 2011/12/21 00:00 [received]
PHST- 2012/05/14 00:00 [revised]
PHST- 2012/05/15 00:00 [accepted]
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
AID - S0303-8467(12)00275-2 [pii]
AID - 10.1016/j.clineuro.2012.05.015 [doi]
PST - ppublish
SO  - Clin Neurol Neurosurg. 2013 Mar;115(3):270-5. doi: 
      10.1016/j.clineuro.2012.05.015. Epub 2012 Jun 12.