PMID- 22695613
OWN - NLM
STAT- MEDLINE
DCOM- 20130723
LR  - 20211021
IS  - 2041-4889 (Electronic)
VI  - 3
IP  - 6
DP  - 2012 Jun 14
TI  - A novel role for RIP1 kinase in mediating TNFalpha production.
PG  - e320
LID - 10.1038/cddis.2012.64 [doi]
AB  - Receptor-interacting protein 1 (RIP1) is a Ser/Thr kinase with both 
      kinase-dependent and kinase-independent roles in death receptor signaling. The 
      kinase activity of RIP1 is required for necroptosis, a caspase-independent 
      pathway of programmed cell death. In some cell types, the inhibition of caspases 
      leads to autocrine production of TNFalpha, which then activates necroptosis. Here, we 
      describe a novel role for RIP1 kinase in regulating TNFalpha production after caspase 
      inhibition. Caspase inhibitors activate RIP1 kinase and another protein, EDD, to 
      mediate JNK signaling, which stimulates Sp1-dependent transcription of TNFalpha. This 
      pathway is independent of nuclear factor kappaB and also occurs after Smac 
      mimetic/IAP antagonist treatment or the loss of TNF receptor-associated factor 2 
      (Traf2). These findings implicate cIAP1/2 and Traf2 as negative regulators of 
      this RIP1 kinase-dependent TNFalpha production pathway and suggest a novel role for 
      RIP1 kinase in mediating TNFalpha production under certain conditions.
FAU - Christofferson, D E
AU  - Christofferson DE
AD  - Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
FAU - Li, Y
AU  - Li Y
FAU - Hitomi, J
AU  - Hitomi J
FAU - Zhou, W
AU  - Zhou W
FAU - Upperman, C
AU  - Upperman C
FAU - Zhu, H
AU  - Zhu H
FAU - Gerber, S A
AU  - Gerber SA
FAU - Gygi, S
AU  - Gygi S
FAU - Yuan, J
AU  - Yuan J
LA  - eng
GR  - R37 AG012859/AG/NIA NIH HHS/United States
GR  - R37-012859/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120614
PL  - England
TA  - Cell Death Dis
JT  - Cell death & disease
JID - 101524092
RN  - 0 (Caspase Inhibitors)
RN  - 0 (GTPase-Activating Proteins)
RN  - 0 (Ralbp1 protein, mouse)
RN  - 0 (TNF Receptor-Associated Factor 2)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.3.2.26 (UBR5 protein, mouse)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Caspase Inhibitors/pharmacology
MH  - Caspases/metabolism
MH  - Cell Line
MH  - GTPase-Activating Proteins/*metabolism
MH  - Mice
MH  - Signal Transduction
MH  - TNF Receptor-Associated Factor 2/metabolism
MH  - Tumor Necrosis Factor-alpha/*biosynthesis
MH  - Ubiquitin-Protein Ligases/metabolism
PMC - PMC3388236
EDAT- 2012/06/15 06:00
MHDA- 2013/07/24 06:00
PMCR- 2012/06/01
CRDT- 2012/06/15 06:00
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2013/07/24 06:00 [medline]
PHST- 2012/06/01 00:00 [pmc-release]
AID - cddis201264 [pii]
AID - 10.1038/cddis.2012.64 [doi]
PST - epublish
SO  - Cell Death Dis. 2012 Jun 14;3(6):e320. doi: 10.1038/cddis.2012.64.