PMID- 22695741
OWN - NLM
STAT- MEDLINE
DCOM- 20121107
LR  - 20120730
IS  - 1745-7270 (Electronic)
IS  - 1672-9145 (Linking)
VI  - 44
IP  - 8
DP  - 2012 Aug
TI  - Association of TNF-alpha promoter polymorphisms with the outcome of persistent HBV 
      infection in a northeast Chinese Han population.
PG  - 712-8
LID - 10.1093/abbs/gms046 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) plays an important role in the pathogenesis and 
      clinical outcome of chronic hepatitis B virus (HBV) infection. The objective of 
      this study was to evaluate the relationship between functional polymorphisms of 
      TNF-alpha and different outcomes of persistent HBV infection in a northeast Chinese 
      Han population. Here 189 HBV spontaneously recovered subjects (SR), 571 
      HBV-infected patients including 180 chronic hepatitis B (CHB), 196 liver 
      cirrhosis (LC), and 195 hepatocellular carcinoma (HCC) individuals were enrolled 
      in this study. All the samples were genotyped for TNF-alpha -857C/T and -863C/A using 
      the polymerase chain reaction-restriction fragment length polymorphism method. 
      The frequency of -857CC genotype was significantly higher in CHB and LC 
      individuals compared with that of SR subjects (P= 0.03, OR = 1.57, 95% CI 
      1.04-2.39 and P= 0.03, OR = 1.57, 95% CI 1.04-2.35, respectively). A significant 
      difference in the distribution of the allele -857C was observed for both CHB vs. 
      SR (P= 0.01, OR = 1.52, 95% CI 1.08-2.13) and LC vs. SR (P= 0.02, OR = 1.47, 95% 
      CI 1.06-2.04) cohorts. In addition, the frequency of -863AA genotype was 
      significantly higher in CHB and LC patients than that of SR subjects (P= 0.01, OR 
      = 3.90, 95% CI 1.35-11.23 and P= 0.01, OR = 3.83, 95% CI 1.34-10.96, 
      respectively), and allele -863A frequency was significantly more common in CHB, 
      LC, and HCC cohorts than that of SR controls (P= 0.004, OR = 1.72, 95% CI 
      1.19-2.50; P= 0.001, OR = 1.81, 95% CI 1.26-2.61 and P= 0.001, OR = 1.90, 95% CI 
      1.33-2.73, respectively). Our data also revealed that haplotype CA was strongly 
      associated with persistent HBV infection. These results suggest an association 
      between the TNF-alpha promoter variants and different outcomes of persistent HBV 
      infection in the studied population.
FAU - Qiu, Bing
AU  - Qiu B
AD  - Department of Gastroenterology, Heilongjiang Province Hospital, Harbin 150036, 
      China. bingqiu07@163.com
FAU - Wang, Xi
AU  - Wang X
FAU - Zhang, Peiyi
AU  - Zhang P
FAU - Shi, Chunlin
AU  - Shi C
FAU - Zhang, Jiye
AU  - Zhang J
FAU - Qiu, Wenliang
AU  - Qiu W
FAU - Wang, Wenduo
AU  - Wang W
FAU - Li, Dongfu
AU  - Li D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120613
PL  - China
TA  - Acta Biochim Biophys Sin (Shanghai)
JT  - Acta biochimica et biophysica Sinica
JID - 101206716
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - China
MH  - Female
MH  - Genotype
MH  - Hepatitis B/*genetics/therapy/virology
MH  - Hepatitis B virus/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction/methods
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - *Promoter Regions, Genetic
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2012/06/15 06:00
MHDA- 2012/11/08 06:00
CRDT- 2012/06/15 06:00
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2012/11/08 06:00 [medline]
AID - gms046 [pii]
AID - 10.1093/abbs/gms046 [doi]
PST - ppublish
SO  - Acta Biochim Biophys Sin (Shanghai). 2012 Aug;44(8):712-8. doi: 
      10.1093/abbs/gms046. Epub 2012 Jun 13.