PMID- 22696494
OWN - NLM
STAT- MEDLINE
DCOM- 20130801
LR  - 20160511
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Linking)
VI  - 14
IP  - 2
DP  - 2013 Feb
TI  - Left atrial volume and function in patients following ST elevation myocardial 
      infarction and the association with clinical outcome: a cardiovascular magnetic 
      resonance study.
PG  - 118-27
LID - 10.1093/ehjci/jes118 [doi]
AB  - AIMS: The left atrium (LA) transfers blood to the left ventricle in a complex 
      manner. LA function is characterized by passive emptying (LA passive fraction), 
      active emptying (LA ejection fraction), and total emptying (LA fractional 
      change). Despite this complexity, the clinical relevance of the LA is based 
      almost exclusively on LA maximal volume (LAmax), which may not glean the full 
      prognostic potential. Cardiovascular magnetic resonance (CMR) is considered the 
      most accurate method for studying LA function and size. The aim of the present 
      study was to evaluate the prognostic importance of LA function in patients 
      following ST elevation myocardial infarction (STEMI). METHODS AND RESULTS: In 199 
      patients, a CMR scan was performed within 1-3 days after STEMI to measure LAmax 
      and minimal volume (LAmin) and LA function. The incidence of death, 
      re-infarction, stroke, and admission for heart failure [major adverse cardiac 
      event (MACE)] were registered during the follow-up period [2.3 years 
      (inter-quartile range: 2.0-2.5)]. A total of 40 patients (20%) met the clinical 
      endpoint of MACE during follow-up. In a Cox regression analysis adjusting for 
      known risk factors, LA fractional change remained independently associated with 
      MACE [adjusted hazard ratio: 0.66 (95% confidence interval: 0.46-0.95)]. LAmax, 
      LAmin, or LA passive fraction was not independently associated with MACE. 
      Furthermore, LA fractional change provided incremental prognostic value to LAmax 
      and other known predictors (Wald chi(2) 31.0 vs. 39.9, P= 0.016). CONCLUSION: In 
      STEMI patients, impaired LA fractional change is independently associated with 
      outcome and provide incremental prognostic information to established predictors 
      including LAmax.
FAU - Lonborg, Jacob Thomsen
AU  - Lonborg JT
AD  - Department of Cardiology, University of Copenhagen, Blegdamsvej 9, 2100 
      Copenhagen, Rigshospitalet, Denmark. Jacoblonborg@gmail.com
FAU - Engstrom, Thomas
AU  - Engstrom T
FAU - Moller, Jacob Eifer
AU  - Moller JE
FAU - Ahtarovski, Kiril A
AU  - Ahtarovski KA
FAU - Kelbaek, Henning
AU  - Kelbaek H
FAU - Holmvang, Lene
AU  - Holmvang L
FAU - Jorgensen, Erik
AU  - Jorgensen E
FAU - Helqvist, Steffen
AU  - Helqvist S
FAU - Saunamaki, Kari
AU  - Saunamaki K
FAU - Soholm, Helle
AU  - Soholm H
FAU - Andersen, Mads
AU  - Andersen M
FAU - Mathiasen, Anders B
AU  - Mathiasen AB
FAU - Kuhl, Jorgen Tobias
AU  - Kuhl JT
FAU - Clemmensen, Peter
AU  - Clemmensen P
FAU - Kober, Lars
AU  - Kober L
FAU - Vejlstrup, Niels
AU  - Vejlstrup N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120612
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Atrial Function, Left/*physiology
MH  - *Electrocardiography
MH  - Female
MH  - Heart Function Tests
MH  - Humans
MH  - Linear Models
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis/mortality
MH  - Organ Size
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Stroke Volume/physiology
MH  - Survival Rate
EDAT- 2012/06/15 06:00
MHDA- 2013/08/02 06:00
CRDT- 2012/06/15 06:00
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2013/08/02 06:00 [medline]
AID - jes118 [pii]
AID - 10.1093/ehjci/jes118 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2013 Feb;14(2):118-27. doi: 10.1093/ehjci/jes118. 
      Epub 2012 Jun 12.