PMID- 22697266
OWN - NLM
STAT- MEDLINE
DCOM- 20130613
LR  - 20191112
IS  - 1875-6166 (Electronic)
IS  - 1871-5249 (Linking)
VI  - 12
IP  - 3
DP  - 2012 Sep
TI  - Emerging RNA-based drugs: siRNAs, microRNAs and derivates.
PG  - 217-32
AB  - An emerging new category of therapeutic agents based on ribonucleic acid has 
      emerged and shown very promising in vitro, animal and pre-clinical results, known 
      as small interfering RNAs (siRNAs), microRNAs mimics (miRNA mimics) and their 
      derivates. siRNAs are small RNA molecules that promote potent and specific 
      silencing of mutant, exogenous or aberrant genes through a mechanism known as RNA 
      interference. These agents have called special attention to medicine since they 
      have been used to experimentally treat a series of neurological conditions with 
      distinct etiologies such as prion, viral, bacterial, fungal, genetic disorders 
      and others. siRNAs have also been tested in other scenarios such as: control of 
      anxiety, alcohol consumption, drug-receptor blockage and inhibition of pain 
      signaling. Although in a much earlier stage, miRNAs mimics, anti-miRs and small 
      activating RNAs (saRNAs) also promise novel therapeutic approaches to control 
      gene expression. In this review we intend to introduce clinicians and medical 
      researchers to the most recent advances in the world of siRNA- and miRNA-mediated 
      gene control, its history, applications in cells, animals and humans, delivery 
      methods (an yet unsolved hurdle), current status and possible applications in 
      future clinical practice.
FAU - Pereira, Tiago Campos
AU  - Pereira TC
AD  - Department of Biology, Sciences and Languages of Ribeirao Preto - FFCLRP, 
      University of Sao Paulo - USP, Ribeirao Preto, SP, Brazil. 
      tiagocampospereira@ffclrp.usp.br
FAU - Lopes-Cendes, Iscia
AU  - Lopes-Cendes I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Cent Nerv Syst Agents Med Chem
JT  - Central nervous system agents in medicinal chemistry
JID - 101269163
RN  - 0 (MicroRNAs)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (RNA, Small Interfering)
SB  - IM
MH  - Animals
MH  - Drug Discovery/methods/*trends
MH  - Gene Transfer Techniques/trends
MH  - Genetic Therapy/methods/*trends
MH  - Humans
MH  - Mental Disorders/genetics/therapy
MH  - MicroRNAs/*administration & dosage/*genetics
MH  - Nervous System Diseases/genetics/therapy
MH  - Pharmaceutical Preparations/administration & dosage
MH  - RNA, Small Interfering/*administration & dosage/*genetics
EDAT- 2012/06/16 06:00
MHDA- 2013/06/14 06:00
CRDT- 2012/06/16 06:00
PHST- 2012/03/06 00:00 [received]
PHST- 2012/05/03 00:00 [revised]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2013/06/14 06:00 [medline]
AID - CMCCNSA-EPUB-20120611-1 [pii]
AID - 10.2174/187152412802430138 [doi]
PST - ppublish
SO  - Cent Nerv Syst Agents Med Chem. 2012 Sep;12(3):217-32. doi: 
      10.2174/187152412802430138.