PMID- 22698927
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20231213
IS  - 1090-2163 (Electronic)
IS  - 0008-8749 (Linking)
VI  - 277
IP  - 1-2
DP  - 2012 May-Jun
TI  - Butyrate interferes with the differentiation and function of human 
      monocyte-derived dendritic cells.
PG  - 66-73
LID - 10.1016/j.cellimm.2012.05.011 [doi]
AB  - Dendritic cells (DCs) are specialized antigen-presenting cells that are uniquely 
      capable of either inducing immune responses or maintaining a state of 
      self-tolerance, depending on their stage of maturation. In the present study, we 
      describe a way to interfere with DCs maturation. The compound butyrate can affect 
      the differentiation of DCs generated from human monocytes and can inhibit T cell 
      proliferation. We demonstrate that butyrate substantially down-regulates the 
      expression of CD80, CD83, and MHC class II molecules; increases endocytic 
      capability; reduces allostimulatory abilities; promote interleukin-10 (IL-10) 
      production; and inhibits interleukin-12 (IL-12) and interferon-gamma (IFN-gamma) 
      production. These results demonstrate a specific immune suppression property of 
      butyrate and supports further investigation for butyrate as a new 
      immunotherapeutic agent.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Liu, Lu
AU  - Liu L
AD  - Department of Gastrointestinal Surgery, Sun Yat-Sen Memorial Hospital, Sun 
      Yat-Sen University, Guangzhou, China.
FAU - Li, Lin
AU  - Li L
FAU - Min, Jun
AU  - Min J
FAU - Wang, Jie
AU  - Wang J
FAU - Wu, Heng
AU  - Wu H
FAU - Zeng, Yujie
AU  - Zeng Y
FAU - Chen, Shuang
AU  - Chen S
FAU - Chu, Zhonghua
AU  - Chu Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120529
PL  - Netherlands
TA  - Cell Immunol
JT  - Cellular immunology
JID - 1246405
RN  - 0 (Antigens, CD)
RN  - 0 (B7-1 Antigen)
RN  - 0 (Butyrates)
RN  - 0 (Cytokines)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Antigens, CD/biosynthesis
MH  - B7-1 Antigen/biosynthesis
MH  - Butyrates/*pharmacology
MH  - Cell Differentiation/*drug effects
MH  - Cells, Cultured
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/cytology/*drug effects
MH  - Down-Regulation/drug effects
MH  - Endocytosis/drug effects
MH  - HLA-DR Antigens/biosynthesis
MH  - Humans
MH  - Immunoglobulins/biosynthesis
MH  - Immunosuppression Therapy
MH  - Membrane Glycoproteins/biosynthesis
MH  - Monocytes/drug effects
MH  - CD83 Antigen
EDAT- 2012/06/16 06:00
MHDA- 2012/10/30 06:00
CRDT- 2012/06/16 06:00
PHST- 2011/08/18 00:00 [received]
PHST- 2012/03/18 00:00 [revised]
PHST- 2012/05/18 00:00 [accepted]
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
AID - S0008-8749(12)00108-6 [pii]
AID - 10.1016/j.cellimm.2012.05.011 [doi]
PST - ppublish
SO  - Cell Immunol. 2012 May-Jun;277(1-2):66-73. doi: 10.1016/j.cellimm.2012.05.011. 
      Epub 2012 May 29.