PMID- 22700599
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20161018
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 167
IP  - 3
DP  - 2012 Sep
TI  - Geographic variations in the frequency of thyroid disorders and thyroid 
      peroxidase antibodies in persons without former thyroid disease within Germany.
PG  - 363-71
LID - 10.1530/EJE-12-0111 [doi]
AB  - OBJECTIVE: To investigate regional variations in the frequency of undiagnosed 
      thyroid disorders among 25- to 88-year-old men and women in two communities in 
      the northeast and the south of Germany. In addition, autoantibodies to 
      thyroperoxidase (TPO-Abs) and urinary iodine excretion were determined. METHODS: 
      Two population-based surveys of men and women using a common standardized 
      protocol, the Study of Health in Pomerania (SHIP) in the northeast of Germany 
      (2505 participants) and the Kooperative Gesundheitsforschung in der Region 
      Augsburg (KORA) in the south of Germany (2316 participants), were compared with 
      regard to the frequency of undiagnosed thyroid disorders. RESULTS: Compared with 
      the northeast of Germany, urinary iodine excretion and serum thyroid-stimulating 
      hormone (TSH) levels were significantly higher in the south. The median urinary 
      iodine concentration was 110 mug/l (64; 169 mug/l) in SHIP and 151 mug/l (97; 214 
      mug/l) in KORA, and the median TSH value was 0.81 mIU/l (0.56; 1.15 mIU/l) in SHIP 
      and 1.22 mIU/l (0.84; 1.80 mIU/l) in KORA. The frequency of elevated TSH (TSH >/= 
      2.12 mIU/l) was 4.3% in SHIP and 14.1% in KORA (P<0.001); the corresponding 
      values for suppressed TSH (<0.25 mIU/l) were 3.5 and 1.7% (P<0.001). The 
      proportion of ultrasonographic findings was 55.5% in SHIP and 68.0% in KORA. The 
      frequency of serum TPO-Abs did not differ significantly between northeast and 
      south Germany. CONCLUSIONS: There were considerable regional disparities in the 
      frequency of thyroid disorders within Germany. These differences can be explained 
      not only by different regional histories of natural iodine deficiency but also by 
      current differences in the iodine supply under an identical nationwide iodine 
      fortification program.
FAU - Meisinger, C
AU  - Meisinger C
AD  - Helmholtz Zentrum Munchen, Institute of Epidemiology II, German Research Center 
      for Environmental Health (GmbH), Neuherberg, Germany. 
      christa.meisinger@helmholtz-muenchen.de
FAU - Ittermann, T
AU  - Ittermann T
FAU - Wallaschofski, H
AU  - Wallaschofski H
FAU - Heier, M
AU  - Heier M
FAU - Below, H
AU  - Below H
FAU - Kramer, A
AU  - Kramer A
FAU - Doring, A
AU  - Doring A
FAU - Nauck, M
AU  - Nauck M
FAU - Volzke, H
AU  - Volzke H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120613
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Autoantibodies)
RN  - EC 1.11.1.8 (Iodide Peroxidase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Autoantibodies/*biosynthesis
MH  - Female
MH  - Germany/epidemiology
MH  - Humans
MH  - Iodide Peroxidase/*immunology
MH  - Male
MH  - Middle Aged
MH  - *Population Surveillance/methods
MH  - Thyroid Diseases/*enzymology/epidemiology/*immunology
EDAT- 2012/06/16 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/06/16 06:00
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - EJE-12-0111 [pii]
AID - 10.1530/EJE-12-0111 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 2012 Sep;167(3):363-71. doi: 10.1530/EJE-12-0111. Epub 2012 Jun 
      13.