PMID- 22701452
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 3
DP  - 2012
TI  - New advances in the development of a vaccine against paracoccidioidomycosis.
PG  - 212
LID - 10.3389/fmicb.2012.00212 [doi]
LID - 212
AB  - Paracoccidioidomycosis (PCM) is an endemic Latin American mycosis caused by 
      Paracoccidioides brasiliensis and also by the recently described P. lutzii. The 
      systemic mycosis is the 10th leading cause of death due to infectious diseases in 
      Brazil. As published, 1,853 patients died of PCM in the 1996-2006 decade in this 
      country. The main diagnostic antigen of P.brasiliensis is the 43 kDa glycoprotein 
      gp43, and its 15-mer peptide QTLIAIHTLAIRYAN, known as P10, contains the T-CD4(+) 
      epitope that elicits an IFN-gamma-mediated Th1 immune response, which effectively 
      treats mice intratracheally infected with PCM. The association of peptide P10 
      with antifungal drugs rendered an additive protective effect, even in 
      immunosuppressed animals, being the basis of a recommended treatment protocol. 
      Other immunotherapeutic tools include a peptide carrying a B cell epitope as well 
      as protective anti-gp43 monoclonal antibodies. New delivery systems and gene 
      therapy have been studied in prophylactic and therapeutic protocols to improve 
      the efficacy of the recognized antigens aiming at a future vaccine as co-adjuvant 
      therapy in patients with PCM.
FAU - Travassos, Luiz R
AU  - Travassos LR
AD  - Department of Microbiology, Immunology and Parasitology, Federal University of 
      Sao Paulo, sao Paulo, Brazil.
FAU - Taborda, C P
AU  - Taborda CP
LA  - eng
PT  - Journal Article
DEP - 20120612
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC3373149
OTO - NOTNLM
OT  - P. brasiliensis
OT  - P. lutzii
OT  - immunotherapy
OT  - paracoccidioidomycosis
OT  - vaccine
EDAT- 2012/06/16 06:00
MHDA- 2012/06/16 06:01
PMCR- 2012/06/12
CRDT- 2012/06/16 06:00
PHST- 2012/05/06 00:00 [received]
PHST- 2012/05/24 00:00 [accepted]
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/06/16 06:01 [medline]
PHST- 2012/06/12 00:00 [pmc-release]
AID - 10.3389/fmicb.2012.00212 [doi]
PST - epublish
SO  - Front Microbiol. 2012 Jun 12;3:212. doi: 10.3389/fmicb.2012.00212. eCollection 
      2012.