PMID- 22702063
OWN - NLM
STAT- MEDLINE
DCOM- 20130215
LR  - 20211203
IS  - 1002-1892 (Print)
IS  - 1002-1892 (Linking)
VI  - 26
IP  - 5
DP  - 2012 May
TI  - [Progress and extensive meaning of mammalian target of rapamycin involved in 
      restoration of nervous system injury].
PG  - 625-30
AB  - OBJECTIVE: To review the possible mechanisms of the mammalian target of rapamycin 
      (mTOR) in the neuronal restoration process after nervous system injury. METHODS: 
      The related literature on mTOR in the restoration of nervous system injury was 
      extensively reviewed and comprehensively analyzed. RESULTS: mTOR can integrate 
      signals from extracellular stress and then plays a critical role in the 
      regulation of various cell biological processes, thus contributes to the 
      restoration of nervous system injury. CONCLUSION: Regulating the activity of mTOR 
      signaling pathway in different aspects can contribute to the restoration of 
      nervous system injury via different mechanisms, especially in the stress-induced 
      brain injury. mTOR may be a potential target for neuronal restoration mechanism 
      after nervous system injury.
FAU - Chen, Hongju
AU  - Chen H
AD  - Department of Pediatrics, Key Laboratory of Obstetric & Gynecologic and Pediatric 
      Diseases and Birth Defects of Ministry of Education, West China Second University 
      Hospital, Sichuan University, Chengdu Sichuan 610041, PR China.
FAU - Tang, Binzhi
AU  - Tang B
FAU - Qu, Yi
AU  - Qu Y
FAU - Mu, Dezhi
AU  - Mu D
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
JT  - Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = 
      Chinese journal of reparative and reconstructive surgery
JID - 9425194
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Protein Kinase Inhibitors)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Brain Injuries/*metabolism/physiopathology
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - Hypoxia-Ischemia, Brain/metabolism/physiopathology
MH  - Neovascularization, Physiologic
MH  - Nerve Tissue Proteins/*metabolism
MH  - Neurons/*metabolism/physiology
MH  - Oxidative Stress
MH  - Protein Kinase Inhibitors/pharmacology
MH  - Protein Kinases/*metabolism
MH  - Signal Transduction/physiology
MH  - Sirolimus/pharmacology
MH  - TOR Serine-Threonine Kinases/antagonists & inhibitors/*metabolism
MH  - Trauma, Nervous System/*metabolism/physiopathology
EDAT- 2012/06/19 06:00
MHDA- 2013/02/16 06:00
CRDT- 2012/06/19 06:00
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2013/02/16 06:00 [medline]
PST - ppublish
SO  - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012 May;26(5):625-30.