PMID- 22702645
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20221207
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 13
IP  - 8
DP  - 2012 Dec
TI  - Soluble CD40L in children and adolescents with type 1 diabetes: relation to 
      microvascular complications and glycemic control.
PG  - 616-24
LID - 10.1111/j.1399-5448.2012.00881.x [doi]
AB  - CD40-soluble CD40 ligand (sCD40L) interactions might constitute an important 
      mediator for vascular inflammation that initiates diabetic microangiopathy. 
      Little is known about the relation between sCD40L and glycemic control. 
      Therefore, this study aimed to evaluate sCD40L levels in patients with type 1 
      diabetes and its relation to microvascular complications and metabolic control. 
      Sixty patients with type 1 diabetes were compared with 30 healthy control 
      subjects. Detailed medical history, thorough clinical examination, and laboratory 
      assessment of high-sensitivity C-reactive protein, glycemic control, and the 
      presence of microvascular complications were performed. Measurement of serum 
      sCD40L levels was done using enzyme-linked immunosorbent assay. Patients were 
      divided into two groups according to the presence of microvascular complications. 
      Serum sCD40L levels were significantly elevated in patients with type 1 diabetes 
      in both groups compared with healthy controls (p < 0.001). Patients with 
      microvascular complications had higher serum sCD40L concentrations than 
      non-complicated cases (median, 13 000 vs. 450 pg/mL; p < 0.001). Serum sCD40L 
      cutoff value of 530 pg/mL was able to differentiate complicated from 
      non-complicated cases (p < 0.001). Patients with microalbuminuria or peripheral 
      neuropathy showed higher levels of sCD40L when compared with patients without 
      these complications (p < 0.05). Serum sCD40L levels were positively correlated 
      with hemoglobin A1c and urinary albumin excretion (p < 0.001). We suggest that 
      serum sCD40L levels are elevated in type 1 diabetes, particularly in patients 
      with microvascular complications and a significant correlation with glycemic 
      control exists. Therefore, measurement of serum sCD40L levels in poorly 
      controlled patients would help to identify those at high risk of developing 
      microvascular complications.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - El-Asrar, Mohamed A
AU  - El-Asrar MA
AD  - Department of Pediatrics, Ain Shams University, Cairo, Egypt.
FAU - Adly, Amira Am
AU  - Adly AA
FAU - Ismail, Eman A
AU  - Ismail EA
LA  - eng
PT  - Journal Article
DEP - 20120615
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 147205-72-9 (CD40 Ligand)
SB  - IM
MH  - Adolescent
MH  - Albuminuria
MH  - Blood Glucose/*metabolism
MH  - CD40 Ligand/*blood
MH  - Child
MH  - Diabetes Mellitus, Type 1/*blood
MH  - Diabetic Angiopathies/*blood
MH  - Diabetic Neuropathies/blood
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Male
EDAT- 2012/06/19 06:00
MHDA- 2013/05/03 06:00
CRDT- 2012/06/19 06:00
PHST- 2012/01/10 00:00 [received]
PHST- 2012/04/09 00:00 [revised]
PHST- 2012/04/17 00:00 [accepted]
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
AID - 10.1111/j.1399-5448.2012.00881.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2012 Dec;13(8):616-24. doi: 10.1111/j.1399-5448.2012.00881.x. 
      Epub 2012 Jun 15.