PMID- 22704695
OWN - NLM
STAT- MEDLINE
DCOM- 20130201
LR  - 20211021
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 60
IP  - 1
DP  - 2012 Oct
TI  - Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke 
      in children with sickle cell anemia.
PG  - 302-8
LID - 10.1016/j.cyto.2012.05.017 [doi]
AB  - Sickle cell anemia (SCA) associated cerebrovascular disease includes vascular 
      remodeling, abnormal cerebral blood flow (CBF) and infarction. We studied the 
      relationships between plasma brain derived neurotropic factor (BDNF), platelet 
      derived growth factors (PDGF-AA and -AB/BB) and high trans-cranial Doppler (TCD) 
      velocity, an indication of CBF velocity. Baseline plasma samples from 39 children 
      (19 SCA with abnormal/high TCD [SATCD], 13 SCA with normal TCD [SNTCD] and 7 
      healthy non-SCA), were assayed for BDNF, PDGF-AA and -AB/BB plus 11 other 
      cytokines. The sensitivity, specificity and usefulness of these biomarkers for 
      stroke prediction was investigated. All subject groups were of similar age and 
      gender distribution. Mean BDNF was significantly higher among SATCD than SNTCD 
      (p=0.004) as was mean PDGF-AA (p=0.001). Similarly, mean PDGF-AA was higher among 
      SCA subjects who developed stroke than those who did not (p=0.012). Elevated BDNF 
      and PDGF-AA were good predictors of the presence of abnormally high CBF velocity 
      and were both associated with severity of anemia. Elevated PDGF-AA predicted risk 
      for stroke development. Stroke incidence and high TCD velocity were associated 
      with elevated BDNF and PDGF-AA. These findings suggest a role for BDNF and 
      PDGF-AA in the patho-physiological mechanism of cerebrovascular disease in SCA.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Hyacinth, Hyacinth I
AU  - Hyacinth HI
AD  - Genomics and Hemoglobinopathies Training Program, Department of Microbiology, 
      Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, 
      Atlanta, GA, USA. hhyacinth@msm.edu
FAU - Gee, Beatrice E
AU  - Gee BE
FAU - Adamkiewicz, Thomas V
AU  - Adamkiewicz TV
FAU - Adams, Robert J
AU  - Adams RJ
FAU - Kutlar, Abdullah
AU  - Kutlar A
FAU - Stiles, Jonathan K
AU  - Stiles JK
FAU - Hibbert, Jacqueline M
AU  - Hibbert JM
LA  - eng
GR  - P20 MD003383/MD/NIMHD NIH HHS/United States
GR  - UL-1RR025008/RR/NCRR NIH HHS/United States
GR  - G12 RR003034/RR/NCRR NIH HHS/United States
GR  - U10 HL052193/HL/NHLBI NIH HHS/United States
GR  - U10 HL 52016/HL/NHLBI NIH HHS/United States
GR  - 1R90-HG004151-01/HG/NHGRI NIH HHS/United States
GR  - U01 HL052193/HL/NHLBI NIH HHS/United States
GR  - U10 HL052016/HL/NHLBI NIH HHS/United States
GR  - R90 HG004151/HG/NHGRI NIH HHS/United States
GR  - UL1 TR000454/TR/NCATS NIH HHS/United States
GR  - S21 MD000101/MD/NIMHD NIH HHS/United States
GR  - -RR033062/RR/NCRR NIH HHS/United States
GR  - R21HL92358/HL/NHLBI NIH HHS/United States
GR  - U10 HL 52193/HL/NHLBI NIH HHS/United States
GR  - UL1 RR025008/RR/NCRR NIH HHS/United States
GR  - R21 HL092358/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120615
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Proto-Oncogene Proteins c-sis)
RN  - 0 (platelet-derived growth factor A)
RN  - 0 (platelet-derived growth factor AB)
RN  - 1B56C968OA (Becaplermin)
SB  - IM
EIN - Cytokine. 2013 Apr;62(1):174
MH  - Analysis of Variance
MH  - Anemia, Sickle Cell/*blood/complications/diagnostic imaging
MH  - Becaplermin
MH  - Biomarkers/blood
MH  - Blood Flow Velocity
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cerebrovascular Circulation
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Cytokines/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Platelet-Derived Growth Factor/*metabolism
MH  - Prospective Studies
MH  - Proto-Oncogene Proteins c-sis/metabolism
MH  - Stroke/*blood/diagnostic imaging/etiology
MH  - Ultrasonography, Doppler, Transcranial/*methods
PMC - PMC3429653
MID - NIHMS381098
EDAT- 2012/06/19 06:00
MHDA- 2013/02/05 06:00
PMCR- 2013/10/01
CRDT- 2012/06/19 06:00
PHST- 2012/03/25 00:00 [received]
PHST- 2012/05/09 00:00 [revised]
PHST- 2012/05/17 00:00 [accepted]
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - S1043-4666(12)00213-X [pii]
AID - 10.1016/j.cyto.2012.05.017 [doi]
PST - ppublish
SO  - Cytokine. 2012 Oct;60(1):302-8. doi: 10.1016/j.cyto.2012.05.017. Epub 2012 Jun 
      15.