PMID- 22705587
OWN - NLM
STAT- MEDLINE
DCOM- 20121024
LR  - 20211021
IS  - 1942-0080 (Electronic)
IS  - 1941-9651 (Print)
IS  - 1941-9651 (Linking)
VI  - 5
IP  - 4
DP  - 2012 Jul
TI  - Normal left ventricular myocardial thickness for middle-aged and older subjects 
      with steady-state free precession cardiac magnetic resonance: the multi-ethnic 
      study of atherosclerosis.
PG  - 500-8
LID - 10.1161/CIRCIMAGING.112.973560 [doi]
AB  - BACKGROUND: Increased left ventricular myocardial thickness (LVMT) is a feature 
      of several cardiac diseases. The purpose of this study was to establish standard 
      reference values of normal LVMT with cardiac magnetic resonance and to assess 
      variation with image acquisition plane, demographics, and left ventricular 
      function. METHODS AND RESULTS: End-diastolic LVMT was measured on cardiac 
      magnetic resonance steady-state free precession cine long and short axis images 
      in 300 consecutive participants free of cardiac disease (169 women; 65.6 +/- 8.5 
      years) of the Multi-Ethnic Study of Atherosclerosis cohort. Mean LVMT on short 
      axis images at the mid-cavity level was 5.3 +/- 0.9 mm and 6.3 +/- 1.1 mm for women 
      and men, respectively. The average of the maximum LVMT at the mid-cavity for 
      women/men was 7/9 mm (long axis) and 7/8 mm (short axis). Mean LVMT was 
      positively associated with weight (0.02 mm/kg; P=0.01) and body surface area (1.1 
      mm/m(2); P<0.001). No relationship was found between mean LVMT and age or height. 
      Greater mean LVMT was associated with lower left ventricular end-diastolic volume 
      (0.01 mm/mL; P<0.01), a lower left ventricular end-systolic volume (-0.01 mm/mL; 
      P=0.01), and lower left ventricular stroke volume (-0.01 mm/mL; P<0.05). LVMT 
      measured on long axis images at the basal and mid-cavity level were slightly 
      greater (by 6% and 10%, respectively) than measurements obtained on short axis 
      images; apical LVMT values on long axis images were 20% less than those on short 
      axis images. CONCLUSIONS: Normal values for wall thickness are provided for 
      middle-aged and older subjects. Normal LVMT is lower for women than men. Observed 
      values vary depending on the imaging plane for measurement.
FAU - Kawel, Nadine
AU  - Kawel N
AD  - Radiology and Imaging Sciences Department and National Institute of Biomedical 
      Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, 
      USA.
FAU - Turkbey, Evrim B
AU  - Turkbey EB
FAU - Carr, J Jeffrey
AU  - Carr JJ
FAU - Eng, John
AU  - Eng J
FAU - Gomes, Antoinette S
AU  - Gomes AS
FAU - Hundley, W Gregory
AU  - Hundley WG
FAU - Johnson, Craig
AU  - Johnson C
FAU - Masri, Sofia C
AU  - Masri SC
FAU - Prince, Martin R
AU  - Prince MR
FAU - van der Geest, Rob J
AU  - van der Geest RJ
FAU - Lima, Joao A C
AU  - Lima JA
FAU - Bluemke, David A
AU  - Bluemke DA
LA  - eng
GR  - ZIA EB000072-02/ImNIH/Intramural NIH HHS/United States
GR  - N01HC95169/HL/NHLBI NIH HHS/United States
GR  - N01-HC-95159/HC/NHLBI NIH HHS/United States
GR  - N01-HC-95169/HC/NHLBI NIH HHS/United States
GR  - N01HC95159/HL/NHLBI NIH HHS/United States
GR  - ZIA CL090019-02/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20120615
PL  - United States
TA  - Circ Cardiovasc Imaging
JT  - Circulation. Cardiovascular imaging
JID - 101479935
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Atherosclerosis/pathology
MH  - Cardiac-Gated Imaging Techniques/*methods
MH  - Contrast Media
MH  - Female
MH  - Gadolinium DTPA
MH  - Heart Ventricles/*anatomy & histology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Sex Factors
MH  - Ventricular Function, Left/*physiology
PMC - PMC3412148
MID - NIHMS394310
COIS- Conflict of interest disclosures Dr. Prince has patent agreements with General 
      Electric, Siemens, Philips, Toshiba and Hitachi and received payment for 
      speakers' bureau appointments from Bayer. Dr. van der Geest is a consultant for 
      Medis medical imaging systems.
EDAT- 2012/06/19 06:00
MHDA- 2012/10/25 06:00
PMCR- 2013/07/01
CRDT- 2012/06/19 06:00
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2012/10/25 06:00 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - CIRCIMAGING.112.973560 [pii]
AID - 10.1161/CIRCIMAGING.112.973560 [doi]
PST - ppublish
SO  - Circ Cardiovasc Imaging. 2012 Jul;5(4):500-8. doi: 
      10.1161/CIRCIMAGING.112.973560. Epub 2012 Jun 15.