PMID- 22706868
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20211021
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 138
IP  - 1
DP  - 2012 Jul
TI  - Chronic lymphocytic leukemia/small lymphocytic lymphoma with cyclin D1 positive 
      proliferation centers do not have CCND1 translocations or gains and lack SOX11 
      expression.
PG  - 132-9
LID - 10.1309/AJCPIVKZRMPF93ET [doi]
AB  - Cyclin D1 expression, usually absent in chronic lymphocytic leukemia/small 
      lymphocytic lymphoma (CLL/SLL), has been described in the proliferation centers 
      (PC) of some CLL/SLL. The prevalence of this finding is uncertain, as is the 
      explanation for its occurrence and whether these cases have any other unique 
      features. Cyclin D1 immunohistochemical staining was therefore investigated in 57 
      extramedullary CLL/SLL biopsies. In 6 cases, cyclin D1 immunofluorescence 
      followed by CCND1 fluorescence in situ hybridization (FISH) and PC targeted 
      analysis was performed using a Bioview Duet system. Excluding the prospectively 
      selected cases that had the targeted FISH studies, cyclin D1+ PC were identified 
      in 20% of cases. The cyclin D1+ CLL did not appear pathologically or 
      phenotypically distinctive, though 46% had an interfollicular growth pattern. The 
      cyclin D1+ PCs were SOX11- and lacked CCND1 translocations and gains in 5 of 5 
      informative cases. The recognition of cyclin D1 expression in PC of a significant 
      minority of CLL/SLL can be a diagnostic aid and should not lead to the diagnosis 
      of focal mantle cell lymphoma.
FAU - Gradowski, Joel F
AU  - Gradowski JF
AD  - Division of Hematopathology, Department of Pathology, University of Pittsburgh 
      School of Medicine, Pittsburgh, PA 15213, USA.
FAU - Sargent, Rachel L
AU  - Sargent RL
FAU - Craig, Fiona E
AU  - Craig FE
FAU - Cieply, Kathleen
AU  - Cieply K
FAU - Fuhrer, Kim
AU  - Fuhrer K
FAU - Sherer, Carol
AU  - Sherer C
FAU - Swerdlow, Steven H
AU  - Swerdlow SH
LA  - eng
GR  - UL1 RR024153/RR/NCRR NIH HHS/United States
GR  - UL1 TR000005/TR/NCATS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (SOX11 protein, human)
RN  - 0 (SOXC Transcription Factors)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cyclin D1/*genetics/metabolism
MH  - Female
MH  - Germinal Center/*metabolism/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*diagnosis/genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - SOXC Transcription Factors/*genetics/metabolism
MH  - Translocation, Genetic
PMC - PMC3700540
MID - NIHMS465800
EDAT- 2012/06/19 06:00
MHDA- 2013/01/19 06:00
PMCR- 2013/07/03
CRDT- 2012/06/19 06:00
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
PHST- 2013/07/03 00:00 [pmc-release]
AID - 138/1/132 [pii]
AID - 10.1309/AJCPIVKZRMPF93ET [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2012 Jul;138(1):132-9. doi: 10.1309/AJCPIVKZRMPF93ET.