PMID- 22707193
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20221207
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 39
IP  - 8
DP  - 2012 Aug
TI  - Meta-analysis of MCP-1 promoter -2518 A/G polymorphism and SLE susceptibility.
PG  - 8475-82
LID - 10.1007/s11033-012-1701-1 [doi]
AB  - The aim of this meta-analysis was to summarize results on the association of 
      monocyte chemoattractant protein-1(MCP-1) promoter -2518 A/G polymorphism with 
      systemic lupus erythematosus (SLE) susceptibility. We searches all the 
      publications about the association between MCP-1 promoter -2518 A/G polymorphism 
      and SLE from Pubmed, Elsevier Science Direct, Chinese Biomedical Literature 
      Database, Chinese National Knowledge Infrastructure. The meta-analysis was 
      performed for genotypes AA verse GG, AA+AG verse GG, AA verse AG+GG, and A allele 
      verse G allele in a fixed/random effect model. A total of 14 studies (2,333 cases 
      and 2,391 controls) were included in the meta-analysis. When all groups were 
      pooled, we had not observed significant association between A allele and G allele 
      (OR = 0.94, 95 %CI = 0.79-1.12, P = 0.50). When analysis were restricted to more 
      ethnically homogeneous populations, the similar results were found in European 
      population and Asian population (OR = 1.05, 95 %CI = 0.75-1.46, P = 0.80; OR = 
      1.00, 95 %CI = 0.86-1.17, P = 0.99). However, we had not detected a significant 
      association between MCP-1 promoter -2518 A/G polymorphism and SLE when examining 
      the genotypes AA verse GG, AA+AG verse GG, AA verse AG+GG. The meta-analysis did 
      not demonstrate the association between MCP-1 promoter -2518 A/G polymorphism and 
      SLE.
FAU - Liu, Ting
AU  - Liu T
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Anhui Medical University, Meishan Road, Hefei 230032, Anhui, China.
FAU - Zhai, Jin-Xia
AU  - Zhai JX
FAU - Wang, Han-Yong
AU  - Wang HY
FAU - Wang, Xing-Hua
AU  - Wang XH
FAU - Zou, Li-Wei
AU  - Zou LW
FAU - Fan, Wen-Jing
AU  - Fan WJ
FAU - Ye, Dong-Qing
AU  - Ye DQ
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20120617
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*genetics
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Publication Bias
MH  - White People/genetics
EDAT- 2012/06/19 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/06/19 06:00
PHST- 2012/03/01 00:00 [received]
PHST- 2012/06/06 00:00 [accepted]
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 10.1007/s11033-012-1701-1 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2012 Aug;39(8):8475-82. doi: 10.1007/s11033-012-1701-1. Epub 2012 
      Jun 17.