PMID- 22707663
OWN - NLM
STAT- MEDLINE
DCOM- 20130219
LR  - 20211021
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 2011
DP  - 2011 Mar 8
TI  - Tuberculosis complicated by immune reconstitution inflammatory syndrome in a 
      patient on anti-TNFalpha therapy for Crohn's disease.
LID - 10.1136/bcr.09.2010.3376 [doi]
LID - bcr0920103376
AB  - A 28-year-old man treated with the antitumour necrosis factor alpha (TNFalpha) monoclonal 
      antibody infliximab for Crohn's disease developed pulmonary tuberculosis (TB), 
      despite testing negative for latent TB prior to treatment. On starting anti-TB 
      treatment and withdrawal of the anti-TNFalpha therapy, he deteriorated both 
      clinically and radiologically. He was diagnosed with a flare of Crohn's disease, 
      and immune reconstitution inflammatory syndrome (IRIS) in his right upper lobe 
      and mediastinal lymph nodes, and commenced on oral prednisolone. Anti-TNFalpha 
      therapy was re-introduced, and prednisolone weaned, following 4 months of anti-TB 
      treatment without complication. He made a full recovery from TB, although his 
      Crohn's symptoms continue to be troublesome. There has been no reactivation of TB 
      to date, after 2 years follow-up.
FAU - O'Dowd, Caroline
AU  - O'Dowd C
AD  - Department of Respiratory Medicine, Victoria Infirmary, Glasgow, UK.
FAU - Kewin, Peter
AU  - Kewin P
FAU - Morris, John
AU  - Morris J
FAU - Cotton, Mark
AU  - Cotton M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110308
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - B72HH48FLU (Infliximab)
SB  - IM
MH  - Adult
MH  - Antibodies, Monoclonal/*adverse effects/therapeutic use
MH  - Crohn Disease/*drug therapy
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*chemically induced
MH  - Infliximab
MH  - Male
MH  - Tuberculosis, Pulmonary/*chemically induced
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors
PMC - PMC3063288
COIS- Competing interests None.
EDAT- 2011/01/01 00:00
MHDA- 2013/02/21 06:00
PMCR- 2013/03/08
CRDT- 2012/06/19 06:00
PHST- 2012/06/19 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
PHST- 2013/03/08 00:00 [pmc-release]
AID - 2011/mar05_1/bcr0920103376 [pii]
AID - bcr.09.2010.3376 [pii]
AID - 10.1136/bcr.09.2010.3376 [doi]
PST - epublish
SO  - BMJ Case Rep. 2011 Mar 8;2011:bcr0920103376. doi: 10.1136/bcr.09.2010.3376.