PMID- 22708958
OWN - NLM
STAT- MEDLINE
DCOM- 20121214
LR  - 20120801
IS  - 1557-9042 (Electronic)
IS  - 0897-7151 (Linking)
VI  - 29
IP  - 11
DP  - 2012 Jul 20
TI  - Brain-derived neurotrophic factor (Val66Met) polymorphism does not influence 
      recovery from a post-traumatic vegetative state: a blinded retrospective 
      multi-centric study.
PG  - 2050-9
LID - 10.1089/neu.2011.2184 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a neurotrophin that influences 
      neuronal plasticity throughout life. Emergence from a vegetative state (VS) after 
      a traumatic brain injury (TBI) implies that the brain undergoes plastic changes. 
      A common polymorphism in the BDNF gene--BDNF Val66Met (referred to herein as 
      BDNF(Met))--impairs cognitive function in healthy subjects. The aim of this study 
      was to determine whether the BDNF(Met) polymorphism plays a role in the recovery 
      of consciousness and cognitive functions in patients in a VS after a TBI. 
      Fifty-three patients in a VS 1 month after a TBI were included in the study and 
      genotyped for the BDNF(Met) polymorphism. Scores of levels of cognitive 
      functioning (LCF) at 1, 3, 6, and 12 months post-TBI were retrospectively 
      compared in patients without (Val group), and with (Met group), the BDNF(Met) 
      polymorphism. The BDNF(Met) polymorphism was detected in 20 out of the 53 
      patients. The mean LCF scores in the Val and Met groups were 1.6+/-0.5 and 1.4+/-0.5 
      at 1 month, 2.3+/-0.7 and 2.5+/-1.2 at 3 months, 3.3+/-1.7 and 3.5+/-1.7 at 6 months, and 
      4+/-1.9 and 3.9+/-1.8 at 12 months, respectively (p>0.05). The percentages of 
      patients in the Val and Met groups who emerged from the VS were 36.4% and 30% at 
      3 months, 66.3% and 70% at 6 months, and 70% and 87.5% at 12 months (p>0.05), 
      respectively. These findings provide evidence that the BDNF(Met) polymorphism is 
      not involved in cognitive improvement in patients with a VS following TBI. Future 
      studies should focus on the role of other BDNF polymorphisms in the recovery from 
      a VS.
FAU - Bagnato, Sergio
AU  - Bagnato S
AD  - Unit for Severe Acquired Brain Injuries, Fondazione Istituto "San Raffaele-G. 
      Giglio " Cefalu, Italy. sergiobagnato@gmail.com
FAU - Minafra, Luigi
AU  - Minafra L
FAU - Bravata, Valentina
AU  - Bravata V
FAU - Boccagni, Cristina
AU  - Boccagni C
FAU - Sant'angelo, Antonino
AU  - Sant'angelo A
FAU - Castiglione, Alberto
AU  - Castiglione A
FAU - Andriolo, Maria
AU  - Andriolo M
FAU - Lucca, Lucia Francesca
AU  - Lucca LF
FAU - De Tanti, Antonio
AU  - De Tanti A
FAU - Pistarini, Caterina
AU  - Pistarini C
FAU - Formisano, Rita
AU  - Formisano R
FAU - Dolce, Giuliano
AU  - Dolce G
FAU - Gelfi, Cecilia
AU  - Gelfi C
FAU - Galardi, Giuseppe
AU  - Galardi G
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - J Neurotrauma
JT  - Journal of neurotrauma
JID - 8811626
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain Injuries/complications/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Persistent Vegetative State/etiology/*genetics
MH  - *Polymorphism, Restriction Fragment Length
MH  - *Polymorphism, Single Nucleotide
MH  - Recovery of Function/*genetics
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2012/06/20 06:00
MHDA- 2012/12/15 06:00
CRDT- 2012/06/20 06:00
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2012/12/15 06:00 [medline]
AID - 10.1089/neu.2011.2184 [doi]
PST - ppublish
SO  - J Neurotrauma. 2012 Jul 20;29(11):2050-9. doi: 10.1089/neu.2011.2184.