PMID- 22710489
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20231110
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 224
IP  - 3
DP  - 2012 Dec
TI  - Differential involvement of prelimbic and infralimbic medial prefrontal cortex in 
      discrete cue-induced reinstatement of 3,4-methylenedioxymethamphetamine (MDMA; 
      ecstasy) seeking in rats.
PG  - 377-85
LID - 10.1007/s00213-012-2762-5 [doi]
AB  - RATIONALE: The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA; 
      ecstasy) is a widely abused drug, particularly in adolescent and young adult 
      populations. Although it was shown that MDMA-associated cues reinstate 
      extinguished MDMA seeking in an animal relapse model, there is little information 
      regarding the neural mechanisms underlying this behavior. OBJECTIVES: Because the 
      medial prefrontal cortex (mPFC) plays an important role in relapse to cocaine and 
      methamphetamine seeking, we tested the effects of lidocaine inactivation of 
      prelimbic (PL) and infralimbic (IL) subregions of mPFC on cue-induced relapse to 
      MDMA seeking. METHODS: Rats were trained to respond for MDMA infusions (0.50 
      mg/kg/infusion, i.v.) paired with a discrete cue in daily 2-h sessions. 
      Responding was reinforced contingent on a modified fixed ratio 5 schedule of 
      reinforcement. Cue-induced reinstatement tests were conducted after responding 
      was extinguished in the absence of MDMA and the conditioned cues. Prior to 
      reinstatement tests, rats received bilateral microinjections of either lidocaine 
      (100 mug/0.5 mul/side) or physiological saline (0.5 mul/side) delivered to either PL 
      or IL mPFC. RESULTS: Microinjections of lidocaine into PL completely blocked 
      reinstatement of MDMA-seeking behavior compared with saline microinjections into 
      the same region. Lidocaine microinjections did not, however, have an effect on 
      food-maintained responding, ruling out a nonspecific disruption of motor 
      performance. Conversely, lidocaine inactivation of IL had no effect on 
      reinstatement of MDMA seeking or food-maintained responding. CONCLUSIONS: Our 
      results provide direct support for PL activation in reinstatement of MDMA-seeking 
      behavior. Moreover, akin to cocaine seeking, there appears to be differential 
      involvement of PL and IL subregions in this behavior.
FAU - Ball, Kevin T
AU  - Ball KT
AD  - Department of Psychology, Bloomsburg University of Pennsylvania, 400 E 2nd St, 
      Bloomsburg, PA 17815, USA. kball@bloomu.edu
FAU - Slane, Mylissa
AU  - Slane M
LA  - eng
GR  - R03 DA027960/DA/NIDA NIH HHS/United States
GR  - R15 DA035432/DA/NIDA NIH HHS/United States
GR  - DA027960/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120619
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Hallucinogens)
RN  - 98PI200987 (Lidocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Amphetamine-Related Disorders/physiopathology/*psychology
MH  - Animals
MH  - Behavior, Addictive/physiopathology/*psychology
MH  - Behavior, Animal/*drug effects
MH  - Conditioning, Operant/drug effects
MH  - *Cues
MH  - Drug-Seeking Behavior/*drug effects
MH  - Eating/drug effects
MH  - Extinction, Psychological/drug effects
MH  - Feeding Behavior/drug effects
MH  - Hallucinogens/administration & dosage/*pharmacology
MH  - Infusions, Intravenous
MH  - Lidocaine/administration & dosage
MH  - Limbic System/*drug effects/physiopathology
MH  - Male
MH  - Microinjections
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Prefrontal Cortex/*drug effects/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recurrence
MH  - Reinforcement Schedule
MH  - Time Factors
PMC - PMC4078904
MID - NIHMS405189
COIS- Conflict of Interest: The authors declare no financial conflicts of interest.
EDAT- 2012/06/20 06:00
MHDA- 2013/04/30 06:00
PMCR- 2014/07/02
CRDT- 2012/06/20 06:00
PHST- 2012/03/06 00:00 [received]
PHST- 2012/05/28 00:00 [accepted]
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
PHST- 2014/07/02 00:00 [pmc-release]
AID - 10.1007/s00213-012-2762-5 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2012 Dec;224(3):377-85. doi: 
      10.1007/s00213-012-2762-5. Epub 2012 Jun 19.