PMID- 22711234
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20211021
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Linking)
VI  - 119
IP  - 12
DP  - 2012 Dec
TI  - The effects of prolonged cathodal direct current stimulation on the excitatory 
      and inhibitory circuits of the ipsilateral and contralateral motor cortex.
PG  - 1499-506
LID - 10.1007/s00702-012-0845-4 [doi]
AB  - Weak cathodal transcranial direct current stimulation (tDCS) of the human hand 
      area modulates corticospinal excitability with a suppression of motor-evoked 
      potentials (MEPs) evoked by transcranial magnetic stimulation (TMS). The changes 
      in excitability persist beyond the time of stimulation if tDCS is given for 
      several minutes and can remain stable for an hour or more. The aim of present 
      study was to evaluate whether a long-lasting suppression of cortical excitability 
      could be induced by prolonged cathodal tDCS (20 min of stimulation). We also 
      explored the impact of brain-derived neurotrophic factor (BDNF) gene 
      polymorphisms, on tDCS after-effects. Cortical excitability to single and 
      paired-pulse TMS was evaluated both for the stimulated and contralateral 
      hemisphere, before and up to 24 h after 20 min of cathodal tDCS. We evaluated 
      threshold and amplitude of MEPs, short interval intracortical inhibition (SICI), 
      and intracortical facilitation (ICF). tDCS produced a pronounced suppression of 
      MEP amplitude that was still significant at 3 h after the end of stimulation. The 
      BDNF genotype had not influence on tDCS after-effects. Thresholds for MEPs, SICI 
      and ICF were not affected. No significant effect was observed in the 
      contralateral hemisphere. Twenty minutes of cathodal tDCS is capable of inducing 
      a long-lasting suppression of the excitability of the human motor cortex.
FAU - Di Lazzaro, V
AU  - Di Lazzaro V
AD  - Department of Neurology, Universita Campus Biomedico, Via Alvaro del Portillo 
      200, Rome, Italy. v.dilazzaro@unicampus.it
FAU - Manganelli, F
AU  - Manganelli F
FAU - Dileone, M
AU  - Dileone M
FAU - Notturno, F
AU  - Notturno F
FAU - Esposito, M
AU  - Esposito M
FAU - Capasso, M
AU  - Capasso M
FAU - Dubbioso, R
AU  - Dubbioso R
FAU - Pace, M
AU  - Pace M
FAU - Ranieri, F
AU  - Ranieri F
FAU - Minicuci, G
AU  - Minicuci G
FAU - Santoro, L
AU  - Santoro L
FAU - Uncini, A
AU  - Uncini A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120619
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Functional Laterality/*physiology
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Motor Cortex/*physiology
MH  - Time
MH  - Transcranial Magnetic Stimulation/*methods
EDAT- 2012/06/20 06:00
MHDA- 2013/07/23 06:00
CRDT- 2012/06/20 06:00
PHST- 2012/03/29 00:00 [received]
PHST- 2012/06/02 00:00 [accepted]
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
AID - 10.1007/s00702-012-0845-4 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2012 Dec;119(12):1499-506. doi: 
      10.1007/s00702-012-0845-4. Epub 2012 Jun 19.