PMID- 22711307
OWN - NLM
STAT- MEDLINE
DCOM- 20121214
LR  - 20211021
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 39
IP  - 9
DP  - 2012 Sep
TI  - Association of growth factors, HIF-1 and NF-kappaB expression with proteasomes in 
      endometrial cancer.
PG  - 8655-62
LID - 10.1007/s11033-012-1720-y [doi]
AB  - Insulin-like growth factors (IGFs), vascular endothelial growth factor (VEGF), 
      hypoxia-inducible factor-1 (HIF-1), and nuclear factor kappa-B (NF-kappaB) are known 
      to play an important role in endometrial cancer pathogenesis. However, the 
      proteolytic regulation of these factors is still poorly understood. We studied 
      the correlation between chymotrypsin-like activity of proteasomes and IGF-I, 
      IGF-II, VEGF, HIF-1, and NF-kappaB levels in endometrial cancer tissues. It was shown 
      that the total activity of proteasomes and the activity of the 20S and 26S 
      proteasomes in malignant tumors were significantly higher than those observed in 
      the normal endometrium. Negative relationships between the proteasome activity 
      and IGF-I, HIF-1, and NF-kappaB p50 expressions were found. High 20S proteasome 
      activity was associated with increase of HIF-1 level. Positive relationships 
      between IGF-I expression and two classic forms of NF-kappaB p50 and p65 in 
      endometrial cancer were revealed. The data obtained indicate the possible 
      proteasomal regulation of growth and transcription factors. The major pool of 
      IGF-I is located in the extracellular space, and it is likely that extracellular 
      proteasomes also take part in the regulation of the IGF-I content. The present 
      data show the evidence of proteasome regulation of growth and nuclear factors 
      that can play an important role in cancer pathogenesis.
FAU - Spirina, Ludmila V
AU  - Spirina LV
AD  - Cancer Research Institute of Siberian Branch of Russian Academy of Medical 
      Sciences, Tomsk, Russia. SpirinaLV@oncology.tomsk.ru
FAU - Yunusova, Nataliya V
AU  - Yunusova NV
FAU - Kondakova, Irina V
AU  - Kondakova IV
FAU - Kolomiets, Larisa A
AU  - Kolomiets LA
FAU - Koval, Valeriya D
AU  - Koval VD
FAU - Chernyshova, Alena L
AU  - Chernyshova AL
FAU - Shpileva, Olga V
AU  - Shpileva OV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120619
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (NF-kappa B)
RN  - 0 (Transcription Factors)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
MH  - Endometrial Hyperplasia/genetics/metabolism
MH  - Endometrial Neoplasms/genetics/*metabolism
MH  - Enzyme Activation
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/genetics/*metabolism
MH  - Insulin-Like Growth Factor I/genetics/*metabolism
MH  - Middle Aged
MH  - NF-kappa B/genetics/*metabolism
MH  - Proteasome Endopeptidase Complex/*metabolism
MH  - Transcription Factors/genetics/metabolism
MH  - Transcription, Genetic
MH  - Vascular Endothelial Growth Factor A/genetics/*metabolism
EDAT- 2012/06/20 06:00
MHDA- 2012/12/15 06:00
CRDT- 2012/06/20 06:00
PHST- 2012/02/01 00:00 [received]
PHST- 2012/06/06 00:00 [accepted]
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2012/12/15 06:00 [medline]
AID - 10.1007/s11033-012-1720-y [doi]
PST - ppublish
SO  - Mol Biol Rep. 2012 Sep;39(9):8655-62. doi: 10.1007/s11033-012-1720-y. Epub 2012 
      Jun 19.