PMID- 22715071
OWN - NLM
STAT- MEDLINE
DCOM- 20130617
LR  - 20151119
IS  - 1532-2149 (Electronic)
IS  - 1090-3801 (Linking)
VI  - 17
IP  - 2
DP  - 2013 Feb
TI  - Circadian variation of breakthrough pain in cancer patients.
PG  - 264-70
LID - 10.1002/j.1532-2149.2012.00184.x [doi]
AB  - BACKGROUND: Breakthrough cancer pain (BTP) can place physical, psychological and 
      economic burdens on patients and their productive life. By preventing instead of 
      treating BTP after it occurs, the efficacy of analgesic treatment in cancer 
      patients could be maximized. With this study, we investigated circadian 
      variations in the occurrence of BTP events in cancer patients. METHODS: The 
      circadian variation of BTP was assessed in two different series (group 1, n = 47; 
      group 2, n = 76) of advanced cancer patients suffering from severe chronic pain 
      and undergoing analgesic treatment with major opioids. RESULTS: BTP episodes 
      showed a circadian pattern, with an acrophase occurring at 10:00 a.m. (p < 0.001) 
      in all patients. When the two series of patients were considered separately, an 
      acrophase was similarly observed, with 60% of BTP episodes recorded between 10:00 
      a.m. and 6:00 p.m. The circadian rhythm of BTP was maintained after stratifying 
      the patients according to whether they had bone metastases or visceral 
      metastases. BTP episodes negatively correlated with quality of life. CONCLUSIONS: 
      BTP onset follows a circadian rhythm, with an acrophase occurring in the late 
      morning.
CI  - (c) 2012 European Federation of International Association for the Study of Pain 
      Chapters.
FAU - Saini, A
AU  - Saini A
AD  - Medical Oncology, Department of Clinical and Biological Sciences, San Luigi 
      Gonzaga Hospital, Orbassano, Italy.
FAU - Tucci, M
AU  - Tucci M
FAU - Tampellini, M
AU  - Tampellini M
FAU - Maina, D
AU  - Maina D
FAU - Bouraouia, K
AU  - Bouraouia K
FAU - Giuliano, P L
AU  - Giuliano PL
FAU - Termine, A
AU  - Termine A
FAU - Castellano, M
AU  - Castellano M
FAU - Campagna, S
AU  - Campagna S
FAU - Laciura, P
AU  - Laciura P
FAU - Berruti, A
AU  - Berruti A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120619
PL  - England
TA  - Eur J Pain
JT  - European journal of pain (London, England)
JID - 9801774
RN  - 0 (Analgesics, Opioid)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analgesics, Opioid/therapeutic use
MH  - Breakthrough Pain/drug therapy/*etiology/*physiopathology
MH  - Chronic Pain/drug therapy/etiology
MH  - Circadian Rhythm/*physiology
MH  - Female
MH  - Humans
MH  - Hydrocortisone/metabolism
MH  - Karnofsky Performance Status
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis/physiopathology
MH  - Neoplasms/*complications/*physiopathology
MH  - Pain Measurement
MH  - Palliative Care
MH  - Prospective Studies
MH  - Quality of Life
MH  - Saliva/metabolism
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2012/06/21 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/06/21 06:00
PHST- 2012/05/17 00:00 [accepted]
PHST- 2012/06/21 06:00 [entrez]
PHST- 2012/06/21 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1002/j.1532-2149.2012.00184.x [doi]
PST - ppublish
SO  - Eur J Pain. 2013 Feb;17(2):264-70. doi: 10.1002/j.1532-2149.2012.00184.x. Epub 
      2012 Jun 19.