PMID- 22715132
OWN - NLM
STAT- MEDLINE
DCOM- 20131108
LR  - 20130522
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 41
IP  - 6
DP  - 2013 Jun
TI  - Detection of C-MYC oncogene translocation and copy number change in the 
      normal-dysplasia-carcinoma sequence of the larynx by fluorescence in situ 
      hybridization.
PG  - 515-9
LID - 10.1002/dc.22879 [doi]
AB  - The aim of this study was to determine the translocation and copy number change 
      of the C-MYC gene in patients with laryngeal dysplasia and laryngeal squamous 
      cell carcinoma (LSCC), and to evaluate the prevalence of such expression in 
      relation to the normal-dysplasia-carcinoma sequence. Fluorescent in situ 
      hybridization (FISH) was applied on formalin-fixed paraffin-embedded blocks of 93 
      laryngeal lesion specimens (14 normal epithelium, 15 mild dysplasia, 18 moderate 
      dysplasia, 16 severe dysplasia, 9 carcinoma in situ, and 21 invasive carcinoma). 
      C-MYC translocation was not observed in all laryngeal tissue. The high frequency 
      for C-MYC copy-number increased (100%) in invasive carcinoma: 57.14% 
      amplifications and 42.86% gains, and the positive rate of C-MYC amplification and 
      copy-number change increased with the increasing severity of laryngeal lesions (P 
      < 0.0001). The results suggest that C-MYC may be activated by gain/amplification 
      in LSCC and precancerous lesions. Thus, C-MYC may play an important role in 
      promoting LSCC progression, and early FISH detection of C-MYC may be exploited to 
      set a screening test for laryngeal dysplasia.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Liu, Yu
AU  - Liu Y
AD  - Department of Pathology, Beijing Tongren Hospital, Capital Medical University, 
      Beijing 100730, China.
FAU - Gong, Li-Ping
AU  - Gong LP
FAU - Dong, Xiao-Li
AU  - Dong XL
FAU - Liu, Hong-Gang
AU  - Liu HG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120620
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/diagnosis/*genetics
MH  - Epithelium/pathology
MH  - Female
MH  - *Gene Dosage
MH  - *Genes, myc
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Laryngeal Neoplasms/diagnosis/*genetics
MH  - Male
MH  - Middle Aged
MH  - Precancerous Conditions/*genetics
MH  - *Translocation, Genetic
EDAT- 2012/06/21 06:00
MHDA- 2013/11/10 06:00
CRDT- 2012/06/21 06:00
PHST- 2012/02/07 00:00 [received]
PHST- 2012/04/24 00:00 [accepted]
PHST- 2012/06/21 06:00 [entrez]
PHST- 2012/06/21 06:00 [pubmed]
PHST- 2013/11/10 06:00 [medline]
AID - 10.1002/dc.22879 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2013 Jun;41(6):515-9. doi: 10.1002/dc.22879. Epub 2012 Jun 20.