PMID- 22715136
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20120726
IS  - 1521-3773 (Electronic)
IS  - 1433-7851 (Linking)
VI  - 51
IP  - 31
DP  - 2012 Jul 27
TI  - Studies of inhibitor binding to the [4Fe-4S] cluster of quinolinate synthase.
PG  - 7711-4
LID - 10.1002/anie.201202261 [doi]
AB  - Stop for NadA! A [4Fe-4S] enzyme, NadA, catalyzes the formation of quinolinic 
      acid in de novo nicotinamide adenine dinucleotide (NAD) biosynthesis. A 
      structural analogue of an intermediate, 4,5-dithiohydroxyphthalic acid (DTHPA), 
      has an in vivo NAD biosynthesis inhibiting activity in E. coli. The inhibitory 
      effect can be explained by the coordination of DTHPA thiolate groups to a unique 
      Fe site of the NadA [4Fe-4S] cluster.
CI  - Copyright (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Chan, Alice
AU  - Chan A
AD  - Laboratoire de Chimie de Biologie des Metaux, UMR 5249, Universite Joseph 
      Fourier, Grenoble-1, CNRS-CEA 17, Rue des Martyrs, 38054 Grenoble Cedex 9, 
      France.
FAU - Clemancey, Martin
AU  - Clemancey M
FAU - Mouesca, Jean-Marie
AU  - Mouesca JM
FAU - Amara, Patricia
AU  - Amara P
FAU - Hamelin, Olivier
AU  - Hamelin O
FAU - Latour, Jean-Marc
AU  - Latour JM
FAU - Ollagnier de Choudens, Sandrine
AU  - Ollagnier de Choudens S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120619
PL  - Germany
TA  - Angew Chem Int Ed Engl
JT  - Angewandte Chemie (International ed. in English)
JID - 0370543
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (Iron-Sulfur Proteins)
RN  - 57-04-5 (Dihydroxyacetone Phosphate)
RN  - EC 2.5.- (Alkyl and Aryl Transferases)
RN  - EC 2.5.- (quinolinate synthase, E coli)
SB  - IM
MH  - Alkyl and Aryl Transferases/*antagonists & inhibitors/metabolism
MH  - Binding Sites/drug effects
MH  - Dihydroxyacetone Phosphate/chemistry/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Enzyme Inhibitors/chemistry/*pharmacology
MH  - Escherichia coli Proteins/*antagonists & inhibitors/metabolism
MH  - Iron-Sulfur Proteins/*antagonists & inhibitors/metabolism
MH  - Models, Molecular
MH  - Molecular Structure
MH  - Structure-Activity Relationship
EDAT- 2012/06/21 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/21 06:00
PHST- 2012/03/22 00:00 [received]
PHST- 2012/06/21 06:00 [entrez]
PHST- 2012/06/21 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1002/anie.201202261 [doi]
PST - ppublish
SO  - Angew Chem Int Ed Engl. 2012 Jul 27;51(31):7711-4. doi: 10.1002/anie.201202261. 
      Epub 2012 Jun 19.