PMID- 22715310
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20240412
IS  - 0973-2063 (Electronic)
IS  - 0973-8894 (Print)
IS  - 0973-2063 (Linking)
VI  - 8
IP  - 9
DP  - 2012
TI  - Homology Modeling of Coagulase in Staphylococcus aureus.
PG  - 412-4
LID - 10.6026/97320630008412 [doi]
AB  - The close correlation between the ability of coagulase to clot blood plasma and 
      their capacity to produce disease, and the corresponding absence of this property 
      in nonpathogenic strains, have led to the assumption that the coagulase, plays 
      important role in the pathogenesis of disease. Currently, crystal structure of 
      coagulase in Staphylococcus aureus remains indefinable. Thus, the objectives of 
      this research is to generate the three dimensional model of coagulase in S. 
      aureus by using homology modeling approach. In this study, we used bioinformatics 
      tools and databases such as BLAST (Basic Local Alignment Search Tool), GenBank, 
      PDB (Protein Databank), and Discovery Studio to gain specific functional insights 
      into coagulase. The model was validated using protein structure checking tools 
      such as PROCHECK, Verify 3D and CE (Combinatorial Extension) for reliability. 
      Therefore, structure prediction of coagulase in S. aureus can provide preliminary 
      knowledge for understanding the function of the protein. The information from 
      this finding will provide important information into the action and regulation 
      mechanism of the coagulase protein in S. aureus.
FAU - Mohamed, Noor Asidah
AU  - Mohamed NA
FAU - Mohamed, Ruzianisra
AU  - Mohamed R
FAU - Chong, Teoh Teow
AU  - Chong TT
LA  - eng
PT  - Journal Article
DEP - 20120515
PL  - Singapore
TA  - Bioinformation
JT  - Bioinformation
JID - 101258255
PMC - PMC3374370
OTO - NOTNLM
OT  - Staphylococcus aureus
OT  - Structure prediction
OT  - coagulase
OT  - homology modeling
EDAT- 2012/06/21 06:00
MHDA- 2012/06/21 06:01
PMCR- 2012/01/01
CRDT- 2012/06/21 06:00
PHST- 2012/04/19 00:00 [received]
PHST- 2012/04/26 00:00 [accepted]
PHST- 2012/06/21 06:00 [entrez]
PHST- 2012/06/21 06:00 [pubmed]
PHST- 2012/06/21 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 97320630008412 [pii]
AID - 10.6026/97320630008412 [doi]
PST - ppublish
SO  - Bioinformation. 2012;8(9):412-4. doi: 10.6026/97320630008412. Epub 2012 May 15.