PMID- 22715689
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140730
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 30
IP  - 3
DP  - 2012 Mar
TI  - [Determination of sodium cyclamate in liquor by high performance liquid 
      chromatography-tandem mass spectrometry with linear trap technology].
PG  - 252-5
AB  - An accurate determination of quantitative and confirmative method for sodium 
      cyclamate in liquor by high performance liquid chromatography-tandem mass 
      spectrometry (HPLC-MS/MS) with linear trap technology has been established. 
      Without pretreatment, the sample was directly injected after filtering through a 
      0.2 microm micro filter. The HPLC separation was performed on an Atlantis dC18 
      column (150 mm x 2.1 mm, 3 microm) by gradient elution with methanol and water 
      containing 0.1% (v/v) formic acid. The eluent was determined and confirmed in 
      multiple reaction monitoring-enhanced product ion (MRM-EPI) scan mode. The 
      acquired data from MRM for the quantitative determination, and the product ion 
      spectra were used for library search for qualitative confirmatory analysis. 
      External standard was used for the quantitative determination of sodium cyclamate 
      in liquor, and good linearity (r = 0.9991) was obtained over the range of 1.320 - 
      132.0 microg/L. The limit of detection (LOD, S/N = 3) for sodium cyclamate was 
      0.1 microg/L. The average recoveries ranged from 96.38% to 107.2% at the spiked 
      levels of 2.640, 26.40 and 100.0 microg/L with the relative standard deviations 
      (RSDs) less than 9%. The matching degrees of the spectra for all positive samples 
      were higher than 92%. The method is simple, accurate and efficient for the 
      determination of sodium cyclamate in liquor and particularly suitable for 
      confirmatory analysis of positive samples.
FAU - Fang, Huiwen
AU  - Fang H
AD  - Wuhan Product Quality Supervision and Inspection Institute, Wuhan 430048, China.
FAU - Zhou, Yuan
AU  - Zhou Y
FAU - Lu, Yuepeng
AU  - Lu Y
FAU - Jiang, Xiaoming
AU  - Jiang X
FAU - Yang, Yong
AU  - Yang Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
EDAT- 2012/06/22 06:00
MHDA- 2012/06/22 06:01
CRDT- 2012/06/22 06:00
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/06/22 06:01 [medline]
AID - 10.3724/sp.j.1123.2011.11023 [doi]
PST - ppublish
SO  - Se Pu. 2012 Mar;30(3):252-5. doi: 10.3724/sp.j.1123.2011.11023.