PMID- 22716128
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20211021
IS  - 1744-9081 (Electronic)
IS  - 1744-9081 (Linking)
VI  - 8
DP  - 2012 Jun 20
TI  - Effect of intermittent exposure to ethanol and MDMA during adolescence on 
      learning and memory in adult mice.
PG  - 32
LID - 10.1186/1744-9081-8-32 [doi]
AB  - BACKGROUND: Heavy binge drinking is increasingly frequent among adolescents, and 
      consumption of 3,4-methylenedioxymethamphetamine (MDMA) is often combined with 
      ethanol (EtOH). The long-lasting effects of intermittent exposure to EtOH and 
      MDMA during adolescence on learning and memory were evaluated in adult mice using 
      the Hebb-Williams maze. METHODS: Adolescent OF1 mice were exposed to EtOH 
      (1.25 g/kg) on two consecutive days at 48-h intervals over a 14-day period (from 
      PD 29 to 42). MDMA (10 or 20 mg/kg) was injected twice daily at 4-h intervals 
      over two consecutive days, and this schedule was repeated six days later (PD 33, 
      34, 41 and 42), resulting in a total of eight injections. Animals were initiated 
      in the Hebb-Williams maze on PND 64. The concentration of brain monoamines in the 
      striatum and hippocampus was then measured. RESULTS: At the doses employed, both 
      EtOH and MDMA, administered alone or together, impaired learning in the 
      Hebb-Williams maze, as treated animals required more time to reach the goal than 
      their saline-treated counterparts. The groups treated during adolescence with 
      EtOH, alone or plus MDMA, also presented longer latency scores and needed more 
      trials to reach the acquisition criterion score. MDMA induced a decrease in 
      striatal DA concentration, an effect that was augmented by the co-administration 
      of EtOH. All the treatment groups displayed an imbalance in the interaction 
      DA/serotonin. CONCLUSIONS: The present findings indicate that the developing 
      brain is highly vulnerable to the damaging effects of EtOH and/or MDMA, since 
      mice receiving these drugs in a binge pattern during adolescence exhibit impaired 
      learning and memory in adulthood.
FAU - Vidal-Infer, Antonio
AU  - Vidal-Infer A
AD  - Unidad de Investigacion Psicobiologia de las Drogodependencias, Departamento de 
      Psicobiologia, Facultad de Psicologia, Universitat de Valencia, Avda, Blasco 
      Ibanez 21, 46010, Valencia, Spain.
FAU - Aguilar, Maria A
AU  - Aguilar MA
FAU - Minarro, Jose
AU  - Minarro J
FAU - Rodriguez-Arias, Marta
AU  - Rodriguez-Arias M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120620
PL  - England
TA  - Behav Brain Funct
JT  - Behavioral and brain functions : BBF
JID - 101245751
RN  - 0 (Serotonin Agents)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 333DO1RDJY (Serotonin)
RN  - 3K9958V90M (Ethanol)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Corpus Striatum/drug effects/metabolism
MH  - Dopamine/metabolism
MH  - Ethanol/*pharmacology
MH  - Hippocampus/drug effects/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - Maze Learning/*drug effects
MH  - Memory/*drug effects
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Serotonin/metabolism
MH  - Serotonin Agents/*pharmacology
PMC - PMC3542061
EDAT- 2012/06/22 06:00
MHDA- 2013/04/24 06:00
PMCR- 2012/06/20
CRDT- 2012/06/22 06:00
PHST- 2011/12/20 00:00 [received]
PHST- 2012/05/28 00:00 [accepted]
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
PHST- 2012/06/20 00:00 [pmc-release]
AID - 1744-9081-8-32 [pii]
AID - 10.1186/1744-9081-8-32 [doi]
PST - epublish
SO  - Behav Brain Funct. 2012 Jun 20;8:32. doi: 10.1186/1744-9081-8-32.