PMID- 22716917
OWN - NLM
STAT- MEDLINE
DCOM- 20121214
LR  - 20211021
IS  - 1471-2202 (Electronic)
IS  - 1471-2202 (Linking)
VI  - 13
DP  - 2012 Jun 20
TI  - Modulations of neural activity in auditory streaming caused by spectral and 
      temporal alternation in subsequent stimuli: a magnetoencephalographic study.
PG  - 72
LID - 10.1186/1471-2202-13-72 [doi]
AB  - BACKGROUND: The aim of the present study was to identify a specific neuronal 
      correlate underlying the pre-attentive auditory stream segregation of subsequent 
      sound patterns alternating in spectral or temporal cues. Fifteen participants 
      with normal hearing were presented with series' of two consecutive ABA auditory 
      tone-triplet sequences, the initial triplets being the Adaptation sequence and 
      the subsequent triplets being the Test sequence. In the first experiment, the 
      frequency separation (delta-f) between A and B tones in the sequences was varied 
      by 2, 4 and 10 semitones. In the second experiment, a constant delta-f of 6 
      semitones was maintained but the Inter-Stimulus Intervals (ISIs) between A and B 
      tones were varied. Auditory evoked magnetic fields (AEFs) were recorded using 
      magnetoencephalography (MEG). Participants watched a muted video of their choice 
      and ignored the auditory stimuli. In a subsequent behavioral study both MEG 
      experiments were replicated to provide information about the participants' 
      perceptual state. RESULTS: MEG measurements showed a significant increase in the 
      amplitude of the B-tone related P1 component of the AEFs as delta-f increased. 
      This effect was seen predominantly in the left hemisphere. A significant increase 
      in the amplitude of the N1 component was only obtained for a Test sequence 
      delta-f of 10 semitones with a prior Adaptation sequence of 2 semitones. This 
      effect was more pronounced in the right hemisphere. The additional behavioral 
      data indicated an increased probability of two-stream perception for delta-f = 4 
      and delta-f = 10 semitones with a preceding Adaptation sequence of 2 semitones. 
      However, neither the neural activity nor the perception of the successive 
      streaming sequences were modulated when the ISIs were alternated. CONCLUSIONS: 
      Our MEG experiment demonstrated differences in the behavior of P1 and N1 
      components during the automatic segregation of sounds when induced by an initial 
      Adaptation sequence. The P1 component appeared enhanced in all Test-conditions 
      and thus demonstrates the preceding context effect, whereas N1 was specifically 
      modulated only by large delta-f Test sequences induced by a preceding small 
      delta-f Adaptation sequence. These results suggest that P1 and N1 components 
      represent at least partially-different systems that underlie the neural 
      representation of auditory streaming.
FAU - Chakalov, Ivan
AU  - Chakalov I
AD  - Institute for Biomagnetism and Biosignalanalysis, University of Munster, 
      Malmedyweg 15, 48149, Munster, Germany.
FAU - Draganova, Rossitza
AU  - Draganova R
FAU - Wollbrink, Andreas
AU  - Wollbrink A
FAU - Preissl, Hubert
AU  - Preissl H
FAU - Pantev, Christo
AU  - Pantev C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120620
PL  - England
TA  - BMC Neurosci
JT  - BMC neuroscience
JID - 100966986
SB  - IM
MH  - *Adaptation, Physiological
MH  - Adult
MH  - Analysis of Variance
MH  - Auditory Pathways
MH  - Auditory Perception/*physiology
MH  - Auditory Threshold/physiology
MH  - Brain/*physiology
MH  - *Brain Mapping
MH  - Evoked Potentials, Auditory/*physiology
MH  - Female
MH  - Functional Laterality
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Magnetocardiography
MH  - Male
MH  - Psychophysics
MH  - Reaction Time
MH  - Time Factors
MH  - Young Adult
PMC - PMC3425313
EDAT- 2012/06/22 06:00
MHDA- 2012/12/15 06:00
PMCR- 2012/06/20
CRDT- 2012/06/22 06:00
PHST- 2012/02/11 00:00 [received]
PHST- 2012/05/21 00:00 [accepted]
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/12/15 06:00 [medline]
PHST- 2012/06/20 00:00 [pmc-release]
AID - 1471-2202-13-72 [pii]
AID - 10.1186/1471-2202-13-72 [doi]
PST - epublish
SO  - BMC Neurosci. 2012 Jun 20;13:72. doi: 10.1186/1471-2202-13-72.