PMID- 22716958
OWN - NLM
STAT- MEDLINE
DCOM- 20130404
LR  - 20130424
IS  - 1475-2719 (Electronic)
IS  - 0029-6651 (Linking)
VI  - 71
IP  - 4
DP  - 2012 Nov
TI  - Recent advances in nutrition, genes and brain health.
PG  - 581-91
LID - 10.1017/S0029665112000237 [doi]
AB  - Molecular mechanisms underlying brain structure and function are affected by 
      nutrition throughout the life cycle, with profound implications for health and 
      disease. Responses to nutrition are in turn influenced by individual differences 
      in multiple target genes. Recent advances in genomics and epigenomics are 
      increasing understanding of mechanisms by which nutrition and genes interact. 
      This review starts with a short account of current knowledge on nutrition-gene 
      interactions, focusing on the significance of epigenetics to nutritional 
      regulation of gene expression, and the roles of SNP and copy number variants 
      (CNV) in determining individual responses to nutrition. A critical assessment is 
      then provided of recent advances in nutrition-gene interactions, and especially 
      energy status, in three related areas: (i) mental health and well-being, (ii) 
      mental disorders and schizophrenia, (iii) neurological (neurodevelopmental and 
      neurodegenerative) disorders and Alzheimer's disease. Optimal energy status, 
      including physical activity, has a positive role in mental health. By contrast, 
      sub-optimal energy status, including undernutrition and overnutrition, is 
      implicated in many disorders of mental health and neurology. These actions are 
      mediated by changes in energy metabolism and multiple signalling molecules, e.g. 
      brain-derived neurotrophic factor (BDNF). They often involve epigenetic 
      mechanisms, including DNA methylation and histone modifications. Recent advances 
      show that many brain disorders result from a sophisticated network of 
      interactions between numerous environmental and genetic factors. Personal, social 
      and economic costs of sub-optimal brain health are immense. Future advances in 
      understanding the complex interactions between nutrition, genes and the brain 
      should help to reduce these costs and enhance quality of life.
FAU - Dauncey, M J
AU  - Dauncey MJ
AD  - Wolfson College, University of Cambridge, Cambridge, UK. mjd4@cam.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120503
PL  - England
TA  - Proc Nutr Soc
JT  - The Proceedings of the Nutrition Society
JID - 7505881
SB  - IM
MH  - *Brain
MH  - *Diet
MH  - Energy Intake/genetics
MH  - Energy Metabolism/genetics
MH  - *Epigenesis, Genetic
MH  - Genes
MH  - Humans
MH  - Mental Disorders/*etiology/genetics/metabolism
MH  - *Mental Health
MH  - Nervous System Diseases/*etiology/genetics/metabolism
MH  - Nutrigenomics
MH  - Nutrition Disorders/*complications/genetics
MH  - Nutritional Status
EDAT- 2012/06/22 06:00
MHDA- 2013/04/05 06:00
CRDT- 2012/06/22 06:00
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2013/04/05 06:00 [medline]
AID - S0029665112000237 [pii]
AID - 10.1017/S0029665112000237 [doi]
PST - ppublish
SO  - Proc Nutr Soc. 2012 Nov;71(4):581-91. doi: 10.1017/S0029665112000237. Epub 2012 
      May 3.