PMID- 22718544
OWN - NLM
STAT- MEDLINE
DCOM- 20120830
LR  - 20220309
IS  - 1531-8249 (Electronic)
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 71
IP  - 6
DP  - 2012 Jun
TI  - CD36 in the periphery and brain synergizes in stroke injury in hyperlipidemia.
PG  - 753-64
LID - 10.1002/ana.23569 [doi]
AB  - OBJECTIVE: Hyperlipidemia exacerbates ischemic stroke outcome and increases CD36 
      expression in the postischemic brain as well as in peripheral 
      monocytes/macrophages. By exchanging bone marrow-derived cells between 
      CD36-expressing and CD36-deficient mice, this study investigates the contribution 
      of peripheral CD36 in comparison with that of brain CD36 to stroke pathology in 
      hyperlipidemia. METHODS: Following bone marrow transplantation, mice were fed a 
      high-fat diet for 11 weeks and then subjected to ischemic stroke. Stroke outcome, 
      expression of brain CD36, monocyte chemoattractant protein-1 (MCP-1), CCR2, and 
      plasma MCP-1 levels were determined at 3 days postischemia. CD36 and CCR2 
      expression were also determined in splenocytes incubated with serum obtained from 
      CD36-expressing or CD36-deficient mice. RESULTS: Infiltrating immune cells from 
      the periphery are the major source of CD36 in the postischemic brain and 
      contribute to stroke-induced brain injury. This CD36 effect was dependent on the 
      modulation of MCP-1 and CCR2 expression in peripheral immune cells as well as 
      CD36-expressing cells in the host brain. INTERPRETATION: This study demonstrates 
      that CD36 expressed in the periphery and brain synergize in ischemic brain injury 
      through regulation of the MCP-1/CCR2 chemokine axis in hyperlipidemic conditions.
CI  - Copyright (c) 2012 American Neurological Association.
FAU - Kim, Eunhee
AU  - Kim E
AD  - Burke-Cornell Medical Research Institute, White Plains, NY.
FAU - Febbraio, Maria
AU  - Febbraio M
FAU - Bao, Yi
AU  - Bao Y
FAU - Tolhurst, Aaron T
AU  - Tolhurst AT
FAU - Epstein, Jeffrey M
AU  - Epstein JM
FAU - Cho, Sunghee
AU  - Cho S
LA  - eng
GR  - R01 HL082511-05/HL/NHLBI NIH HHS/United States
GR  - R01 HL082511/HL/NHLBI NIH HHS/United States
GR  - HL82511-04S1/HL/NHLBI NIH HHS/United States
GR  - HL82511/HL/NHLBI NIH HHS/United States
GR  - R01 HL082511-04S1/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (CD36 Antigens)
RN  - 0 (CX3C Chemokine Receptor 1)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Ccr2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CX3CL1)
RN  - 0 (Cx3cl1 protein, mouse)
RN  - 0 (Cx3cr1 protein, mouse)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, Chemokine)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 5.4.- (Intramolecular Transferases)
RN  - EC 5.4.- (marneral synthase, Arabidopsis)
SB  - IM
CIN - Ann Neurol. 2012 Jun;71(6):729-31. PMID: 22718541
MH  - Animals
MH  - Arabidopsis Proteins/metabolism
MH  - Bone Marrow Transplantation
MH  - Brain/*metabolism/pathology
MH  - Brain Injuries/*etiology/metabolism/pathology
MH  - CD36 Antigens/deficiency/*physiology
MH  - CX3C Chemokine Receptor 1
MH  - Chemokine CCL2/metabolism
MH  - Chemokine CX3CL1/genetics/metabolism
MH  - Cholesterol/blood
MH  - Disease Models, Animal
MH  - Gene Expression Regulation/*genetics
MH  - *Hyperlipidemias/complications/metabolism/pathology
MH  - Infarction, Middle Cerebral Artery/complications
MH  - Intramolecular Transferases/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Monocytes/immunology/metabolism/pathology
MH  - Receptors, CCR2/genetics/metabolism
MH  - Receptors, Chemokine/genetics/metabolism
MH  - Time Factors
PMC - PMC3383818
MID - NIHMS360079
COIS- Conflict of interest None
EDAT- 2012/06/22 06:00
MHDA- 2012/08/31 06:00
PMCR- 2013/06/01
CRDT- 2012/06/22 06:00
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/08/31 06:00 [medline]
PHST- 2013/06/01 00:00 [pmc-release]
AID - 10.1002/ana.23569 [doi]
PST - ppublish
SO  - Ann Neurol. 2012 Jun;71(6):753-64. doi: 10.1002/ana.23569.