PMID- 22719740
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 3
DP  - 2012
TI  - Interleukin-2 production by dendritic cells and its immuno-regulatory functions.
PG  - 161
LID - 10.3389/fimmu.2012.00161 [doi]
LID - 161
AB  - Dendritic cells (DCs) are uniquely potent antigen presenting cells that acquire 
      microbial products and prime adaptive immune responses against pathogens. 
      Furthermore, DCs also play a key role in induction and maintenance of tolerance. 
      Although numerous studies have assessed the diverse functions of DCs, many 
      unanswered questions remain regarding the molecular mechanisms that DCs use to 
      achieve immunoregulation. While not widely regarded as a significant provider of 
      T-cell growth factors, DCs have previously been identified as a potential source 
      of IL-2 cytokine. Recent research indicates that microbes are the most effective 
      stimuli to trigger IL-2 production in DCs by activating the calcineurin/NFAT 
      signaling pathway. Herein we describe recent insights into the production and 
      function of IL-2 cytokine and IL-2 receptor in DCs early after stimulation 
      through pattern recognition receptors. These findings clarify how DCs fine-tune 
      effector and regulatory responses by modulating IL-2 production in both tolerance 
      and immunity.
FAU - Zelante, Teresa
AU  - Zelante T
AD  - Singapore Immunology Network, Agency for Science, Technology and Research 
      Singapore.
FAU - Fric, Jan
AU  - Fric J
FAU - Wong, Alicia Y W
AU  - Wong AY
FAU - Ricciardi-Castagnoli, Paola
AU  - Ricciardi-Castagnoli P
LA  - eng
PT  - Journal Article
DEP - 20120618
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3376408
OTO - NOTNLM
OT  - IL-2
OT  - LPS
OT  - NFAT
OT  - calcineurin
OT  - dectin-1
OT  - dendritic cell
EDAT- 2012/06/22 06:00
MHDA- 2012/06/22 06:01
PMCR- 2012/01/01
CRDT- 2012/06/22 06:00
PHST- 2012/03/02 00:00 [received]
PHST- 2012/05/30 00:00 [accepted]
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/06/22 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2012.00161 [doi]
PST - epublish
SO  - Front Immunol. 2012 Jun 18;3:161. doi: 10.3389/fimmu.2012.00161. eCollection 
      2012.