PMID- 22719849
OWN - NLM
STAT- MEDLINE
DCOM- 20121213
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 6
DP  - 2012
TI  - Impact of brain-derived neurotrophic factor Val66Met polymorphism on cortical 
      thickness and voxel-based morphometry in healthy Chinese young adults.
PG  - e37777
LID - 10.1371/journal.pone.0037777 [doi]
LID - e37777
AB  - BACKGROUND: Following voxel-based morphometry (VBM), brain-derived neurotrophic 
      factor (BDNF) Val66Met polymorphism (rs6265) has been shown to affect human brain 
      morphology in Caucasians. However, little is known about the specific role of the 
      Met/Met genotype on brain structure. Moreover, the relationship between BDNF 
      Val66Met polymorphism and Chinese brain morphology has not been studied. 
      METHODOLOGY/PRINCIPAL FINDINGS: The present study investigated brain structural 
      differences among three genotypes of BDNF (rs6265) for the first time in healthy 
      young Chinese adults via cortical thickness analysis and VBM. Brain differences 
      in Met carriers using another grouping method (combining Val/Met and Met/Met 
      genotypes into a group of Met carriers as in most previous studies) were also 
      investigated using VBM. Dual-approach analysis revealed less gray matter (GM) in 
      the frontal, temporal, cingulate and insular cortices in the Met/Met group 
      compared with the Val/Val group (corrected, P<0.05). Areas with less GM in the 
      Val/Met group were included in the Met/Met group. VBM differences in Met carriers 
      were only found in the middle cingulate cortex. CONCLUSIONS/SIGNIFICANCE: The 
      current results indicated a unique pattern of brain morphologic differences 
      caused by BDNF (rs6265) in young Chinese adults, in which the Met/Met genotype 
      markedly affected the frontal, temporal, cingulate, and insular regions. The 
      grouping method with Met carriers was not suitable to detect the genetic effect 
      of BDNF Val66Met polymorphism on brain morphology, at least in the Chinese 
      population, because it may hide some specific roles of Met/Met and Val/Met 
      genotypes on brain structure.
FAU - Yang, Xuejuan
AU  - Yang X
AD  - Life Sciences Research Center, School of Life Sciences and Technology, Xidian 
      University, Xi'an, Shaanxi, China.
FAU - Liu, Peng
AU  - Liu P
FAU - Sun, Jinbo
AU  - Sun J
FAU - Wang, Guihong
AU  - Wang G
FAU - Zeng, Fang
AU  - Zeng F
FAU - Yuan, Kai
AU  - Yuan K
FAU - Liu, Jixin
AU  - Liu J
FAU - Dong, Minghao
AU  - Dong M
FAU - von Deneen, Karen M
AU  - von Deneen KM
FAU - Qin, Wei
AU  - Qin W
FAU - Tian, Jie
AU  - Tian J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120613
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cerebral Cortex/*anatomy & histology
MH  - China
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Methionine/*genetics
MH  - *Polymorphism, Genetic
MH  - Valine/*genetics
MH  - Young Adult
PMC - PMC3374831
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2012/06/22 06:00
MHDA- 2012/12/14 06:00
PMCR- 2012/06/13
CRDT- 2012/06/22 06:00
PHST- 2011/11/03 00:00 [received]
PHST- 2012/04/23 00:00 [accepted]
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/12/14 06:00 [medline]
PHST- 2012/06/13 00:00 [pmc-release]
AID - PONE-D-11-22995 [pii]
AID - 10.1371/journal.pone.0037777 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(6):e37777. doi: 10.1371/journal.pone.0037777. Epub 2012 Jun 13.