PMID- 22720065
OWN - NLM
STAT- MEDLINE
DCOM- 20121213
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 6
DP  - 2012
TI  - Two loci on chromosome 5 are associated with serum IgE levels in Labrador 
      retrievers.
PG  - e39176
LID - 10.1371/journal.pone.0039176 [doi]
LID - e39176
AB  - Crosslinking of immunoglobulin E antibodies (IgE) bound at the surface of mast 
      cells and subsequent mediator release is considered the most important trigger 
      for allergic reactions. Therefore, the genetic control of IgE levels is studied 
      in the context of allergic diseases, such as asthma, atopic rhinitis, or atopic 
      dermatitis (AD). We performed genome-wide association studies in 161 Labrador 
      Retrievers with regard to total and allergen-specific immunoglobulin E (IgE) 
      levels. We identified a genome-wide significant association on CFA 5 with the 
      antigen-specific IgE responsiveness to Acarus siro. We detected a second 
      genome-wide significant association with respect to the antigen-specific IgE 
      responsiveness to Tyrophagus putrescentiae at a different locus on chromosome 5. 
      A. siro and T. putrescentiae both belong to the family Acaridae and represent 
      so-called storage or forage mites. These forage mites are discussed as major 
      allergen sources in canine AD. No obvious candidate gene for the regulation of 
      IgE levels is located under the two association signals. Therefore our studies 
      offer a chance of identifying a novel mechanism controlling the host's IgE 
      response.
FAU - Owczarek-Lipska, Marta
AU  - Owczarek-Lipska M
AD  - Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
FAU - Lauber, Beatrice
AU  - Lauber B
FAU - Molitor, Vivianne
AU  - Molitor V
FAU - Meury, Sabrina
AU  - Meury S
FAU - Kierczak, Marcin
AU  - Kierczak M
FAU - Tengvall, Katarina
AU  - Tengvall K
FAU - Webster, Matthew T
AU  - Webster MT
FAU - Jagannathan, Vidhya
AU  - Jagannathan V
FAU - Schlotter, Yvette
AU  - Schlotter Y
FAU - Willemse, Ton
AU  - Willemse T
FAU - Hendricks, Anke
AU  - Hendricks A
FAU - Bergvall, Kerstin
AU  - Bergvall K
FAU - Hedhammar, Ake
AU  - Hedhammar A
FAU - Andersson, Goran
AU  - Andersson G
FAU - Lindblad-Toh, Kerstin
AU  - Lindblad-Toh K
FAU - Favrot, Claude
AU  - Favrot C
FAU - Roosje, Petra
AU  - Roosje P
FAU - Marti, Eliane
AU  - Marti E
FAU - Leeb, Tosso
AU  - Leeb T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120615
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Chromosome Mapping/*veterinary
MH  - Dog Diseases/blood/*genetics
MH  - Dogs
MH  - Immunoglobulin E/*blood
PMC - PMC3376118
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2012/06/22 06:00
MHDA- 2012/12/14 06:00
PMCR- 2012/06/15
CRDT- 2012/06/22 06:00
PHST- 2012/02/10 00:00 [received]
PHST- 2012/05/16 00:00 [accepted]
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/12/14 06:00 [medline]
PHST- 2012/06/15 00:00 [pmc-release]
AID - PONE-D-12-04164 [pii]
AID - 10.1371/journal.pone.0039176 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(6):e39176. doi: 10.1371/journal.pone.0039176. Epub 2012 Jun 15.