PMID- 22720171
OWN - NLM
STAT- MEDLINE
DCOM- 20130403
LR  - 20230429
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2012
DP  - 2012
TI  - Multiple approaches to investigate the transport and activity-dependent release 
      of BDNF and their application in neurogenetic disorders.
PG  - 203734
LID - 10.1155/2012/203734 [doi]
LID - 203734
AB  - Studies utilizing genetic and pharmacological manipulations in rodent models and 
      neuronal cultures have revealed myriad roles of brain-derived neurotrophic factor 
      (BDNF). Currently, this knowledge of BDNF function is being translated into 
      improvement strategies for several debilitating neurological disorders in which 
      BDNF abnormalities play a prominent role. Common among the BDNF-related disorders 
      are irregular trafficking and release of mature BDNF (mBDNF) and/or its prodomain 
      predecessor, proBDNF. Thus, investigating the conditions required for proper 
      trafficking and release of BDNF is an essential step toward understanding and 
      potentially improving these neurological disorders. This paper will provide 
      examples of disorders related to BDNF release and serve as a review of the 
      techniques being used to study the trafficking and release of BDNF.
FAU - Hartmann, David
AU  - Hartmann D
AD  - Department of Neurobiology, SHEL 1002, Civitan International Research Center, The 
      University of Alabama at Birmingham, Birmingham, AL 35294-2182, USA.
FAU - Drummond, Jana
AU  - Drummond J
FAU - Handberg, Erik
AU  - Handberg E
FAU - Ewell, Sharday
AU  - Ewell S
FAU - Pozzo-Miller, Lucas
AU  - Pozzo-Miller L
LA  - eng
GR  - P30 HD038985/HD/NICHD NIH HHS/United States
GR  - R01 NS040593/NS/NINDS NIH HHS/United States
GR  - R01 NS065027/NS/NINDS NIH HHS/United States
GR  - T32 GM008716/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20120606
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Humans
MH  - Nervous System Diseases/*genetics/*metabolism
MH  - Protein Transport/physiology
PMC - PMC3375105
EDAT- 2012/06/22 06:00
MHDA- 2013/04/04 06:00
PMCR- 2012/06/06
CRDT- 2012/06/22 06:00
PHST- 2012/02/06 00:00 [received]
PHST- 2012/04/14 00:00 [revised]
PHST- 2012/04/15 00:00 [accepted]
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2013/04/04 06:00 [medline]
PHST- 2012/06/06 00:00 [pmc-release]
AID - 10.1155/2012/203734 [doi]
PST - ppublish
SO  - Neural Plast. 2012;2012:203734. doi: 10.1155/2012/203734. Epub 2012 Jun 6.